Summary
We examined the changes in the intracerebral activities, at the time of postmortem autopsy, in patients with Alzheimer's disease. When compared with the control group, the activity of kallikrein-like enzyme was significantly decreased, while prolyl endopeptidase activity increased, in the patients group. Aprotinin inhibited 50% of the activity of the former enzyme at 2×10−7M. Taken together with the results of a multivariate study, the above findings may indicate that intracerebral kallikrein deficiency plays an important role in the pathogenesis of Alzheimer's disease.
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Aoyagi, T., Wada, T., Nagai, M. et al. Deficiency of kallikrein-like enzyme activities in cerebral tissue of patients with alzheimer's disease. Experientia 46, 94–97 (1990). https://doi.org/10.1007/BF01955428
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DOI: https://doi.org/10.1007/BF01955428