Experientia

, Volume 46, Issue 1, pp 69–72 | Cite as

Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension

  • A. L. Lattion
  • J. P. Flückiger
  • B. Waeber
  • J. Nussberger
  • J. F. Aubert
  • H. R. Brunner
Research Articles
  • 11 Downloads

Summary

The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n=11) or a regular-sodium diet (n=10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.

Key words

Renal hypertension sodium atrial natriuretic factor messenger RNA 

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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • A. L. Lattion
    • 1
  • J. P. Flückiger
    • 1
  • B. Waeber
    • 1
  • J. Nussberger
    • 1
  • J. F. Aubert
    • 1
  • H. R. Brunner
    • 1
  1. 1.Division of HypertensionUniversity HositalLausanne(Switzerland)

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