, Volume 46, Issue 1, pp 69–72 | Cite as

Influence of sodium balance on atrial natriuretic factor in rats with one-kidney, one-clip renal hypertension

  • A. L. Lattion
  • J. P. Flückiger
  • B. Waeber
  • J. Nussberger
  • J. F. Aubert
  • H. R. Brunner
Research Articles


The influence of sodium intake on the gene expression and circulating levels of atrial natriuretic factor (ANF) was investigated in unanesthetized rats with one-kidney, one-clip renal hypertension. After clipping, the rats were maintained for 3 weeks either on a salt-deficient (n=11) or a regular-sodium diet (n=10). Animals which had received the regular-sodium diet exhibited significantly higher ANF mRNA levels in their right and left atria than salt-restricted animals, whereas there was no significant difference in plasma ANF levels.

Key words

Renal hypertension sodium atrial natriuretic factor messenger RNA 


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  1. 1.
    Needleman, P., Adams, S. P., Cole, B. R., Currie, G. G., Geller, D. M., Michener, M. L., Saper, C. B., Schwarz, D., and Standaert, D. G., Hypertension7 (1985) 469.PubMedGoogle Scholar
  2. 2.
    De Bold, A. J., Fedn Proc.45 (1986) 2081.Google Scholar
  3. 3.
    Atlas, S. A., and Laragh, J. H., A. Rev. Med.37 (1986) 397.CrossRefGoogle Scholar
  4. 4.
    Genest, J., and Cantin, M., Circulation75 (Suppl. 1) (1987) I-118.Google Scholar
  5. 5.
    Maki, M., Takayanagi, R., Misono, K. S., Pandey, K. N., Tibbets, C., and Inagami, T., Nature309 (1984) 722.CrossRefPubMedGoogle Scholar
  6. 6.
    Seidman, C. E., Duby, A., Choi, E., Graham, R. M., Haber, E., Homcy, G., Smith, J. A., and Seidman, J. G., Science225 (1984) 324.PubMedGoogle Scholar
  7. 7.
    Yamanaka, M., Greenberg, B., Johnson, L., Seilhamer, J., Brewer, M., Friedmann, T., Miller, J., Atlas, S., Laragh, J., Lewicki, J., and Fiddes, J., Nature309 (1984) 719.CrossRefPubMedGoogle Scholar
  8. 8.
    Gavras, H., Brunner, H. R., Vaughan, E. D. Jr, and Laragh, J. H., Science180 (1973) 1369.PubMedGoogle Scholar
  9. 9.
    Waeber, B., Nussberger, J., and Brunner, H. R., Am. J. Physiol.246 (1984) H573.PubMedGoogle Scholar
  10. 10.
    Nussberger, J., Mooser, V., Maridor, G., Juillerat, L., Waeber, B., and Brunner, H. R., (1989) submitted for publication.Google Scholar
  11. 11.
    Glisin, V., Crkvenjakov, R., and Byus, G., Biochemistry13 (1974) 2633.CrossRefPubMedGoogle Scholar
  12. 12.
    Lattion, A. L., Michel, J. B., Arnauld, E., Corvol, P., and Soubrier, F., Am. J. Physiol.251 (1986) H890.PubMedGoogle Scholar
  13. 13.
    Lattion, A. L., Aubert, J. F., Flückiger, J. P., Nussberger, J., Waeber, B., and Brunner, H. R., Am. J. Physiol. (1988) in press.Google Scholar
  14. 14.
    Heinrich, G., Kronenberg, H. M. Jr, Potts, J. T., and Habener, J. F., Endocrinology112 (1983) 449.PubMedGoogle Scholar
  15. 15.
    Brown, T. C., Davis, J. O., Olichney, M. J., and Johnston, C. I., Circ. Res.18 (1966) 475.PubMedGoogle Scholar
  16. 16.
    Miller, E. D., Samuels, A. I., Haber, E., and Barger, A. C., Science177 (1972) 1108.PubMedGoogle Scholar
  17. 17.
    Swales, J. D., Thurston, H., Queiroz, F. P., and Medina, A., J. Lab. clin. Med.80 (1972) 539.PubMedGoogle Scholar
  18. 18.
    Thurston, H., and Swales, J. D., Clin. Sci. molec. Med.51 (1976) 275.Google Scholar
  19. 19.
    Seymour, A. A., Davis, J. O., Freeman, R. H., De Forrest, J. M., Rowe, B. P., Stephens, G. A., and Williams, G. M., Am. J. Physiol.240 (1981) H788.PubMedGoogle Scholar
  20. 20.
    Garcia, R., Cantin, M., Gutkowska, J., and Thibault, G., Hypertension9 (1987) 144.PubMedGoogle Scholar
  21. 21.
    De Leon, H., Castaneda-Hernandez, G., and Hong, E., Life Sci.41 (1987) 341.CrossRefPubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • A. L. Lattion
    • 1
  • J. P. Flückiger
    • 1
  • B. Waeber
    • 1
  • J. Nussberger
    • 1
  • J. F. Aubert
    • 1
  • H. R. Brunner
    • 1
  1. 1.Division of HypertensionUniversity HositalLausanne(Switzerland)

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