, Volume 38, Issue 9, pp 1071–1073 | Cite as

Relationship of specific granules to the natriuretic and diuretic activity of rat atria

  • R. Garcia
  • M. Cantin
  • G. Thibault
  • H. Ong
  • J. Genest
Specialia Physiologica


The isolation of several fractions from rat atrial homogenates, by the use of differential and sucrose gradient centrifugation, indicates that the diuretic and natriuretic activity is restricted to the fractions rich in specific granules. Our preliminary results suggest that the active substance is a small peptide which is probably different from the natriuretic substance(s) already known.


Peptide Sucrose Centrifugation Active Substance Gradient Centrifugation 
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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • R. Garcia
    • 1
  • M. Cantin
    • 1
  • G. Thibault
    • 1
  • H. Ong
    • 1
  • J. Genest
    • 1
  1. 1.Clinical Research Institute of Montreal and Department of Pathology and Faculty of PharmacyUniversity of MontrealMontrealCanada

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