Experientia

, Volume 39, Issue 3, pp 308–310 | Cite as

Natural killer cell activity in fawn-hooded rats

  • J. R. Starkey
  • D. J. Prieur
  • S. S. Ristow
Short Communications

Summary

Fawn-hooded (FH) rats were shown to lack the genetically conditioned defect of natural killer (NK) activity hypothesized to be present by analogy with the Chediak-Higashi syndrome (CHS) in mice and human beings. In 4-h51Cr release assays, splenic NK cells from FH rats killed YAC-1, RL♂ 1 and G1-TC tumor targets without deficiency based upon comparison with cells from BD-IV, BD-IX and NBR inbred rat strains. Progeny of BD×FH F1 rats backcrossed to FH failed to reveal a correlation of reduced NK activity and dilute coat color. From these, and other data presented, it is concluded that despite similarities in coat color dilution and platelet storage pool deficiency, FH rats do not closely resemble CHS mice or human beings in having deficient NK activity and cannot be considered the rat homolog of the CHS.

Keywords

Natural Killer Coat Color Natural Killer Cell Activity Natural Killer Activity Splenic Natural Killer Cell 

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Copyright information

© Birkhäuser Verlag 1983

Authors and Affiliations

  • J. R. Starkey
    • 1
    • 2
  • D. J. Prieur
    • 1
    • 2
  • S. S. Ristow
    • 1
    • 2
  1. 1.Department of Veterinary Microbiology and PathologyWashington State UniversityPullmanUSA
  2. 2.Department of Bacteriology and BiochemistryUniversity of IdahoMoscowUSA

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