Summary
Tris-(2-chloroethyl)amine (TCEA), a strong alkylating agent, not only alkylates protein at the hitherto accepted reactive sites but also at the nitrogen of the peptide bond; this is, however, no hindrance for proteolysis.
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References
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This work was done in the Pharmakologisches Institut der Universität München, Nussbaumstr. 26, D-8000 München 2.
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Albrecht, G.J. Alkylation of protein by Tris-(2-chloroethyl)amine at the peptide bond. Experientia 39, 304–305 (1983). https://doi.org/10.1007/BF01955318
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DOI: https://doi.org/10.1007/BF01955318