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Effect of ketoconazole and miconazole on skeletal muscle mitochondrial calcium transport system

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Both ketoconazole and miconazole inhibit the state 3 respiration induced by Ca2+, stimulate the state 4 respiration during succinate oxidation, inhibit the uptake of Ca2+ and also induce Ca2+ release in the aerobic steady state of skeletal muscle mitochondria. Miconazole is twice as effective as ketoconazole.

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Authors and Affiliations

  1. Muscle Biology Division, Agricultural Research Council, Meat Research Institute, Langford, BS187DY, Bristol, UK

    K. S. Cheah & A. M. Cheah

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  1. K. S. Cheah
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  2. A. M. Cheah
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Cheah, K.S., Cheah, A.M. Effect of ketoconazole and miconazole on skeletal muscle mitochondrial calcium transport system. Experientia 39, 290–293 (1983). https://doi.org/10.1007/BF01955310

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