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A micro-electrode amplifier with an infinite resistance current source for intracellular measurements of membrane potential and resistance changes under current clamp

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Summary

A microelectrode amplifier for intracellular electrophysiological research is described. It is equipped with an electronic infinite resistance constant current source for the injection of current into biological cells. With this amplifier the potential changes, the resistance changes and the dependence on extrinsic current of single cells can be measured independently and simultaneously.

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Literatur

  1. T. Tomita, in: Handbook of Sensory Physiology vol. 7/2, p. 483. Ed. M.G.F. Fuortes, Springer, Berlin-Heidelberg-New York 1972.

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  2. D.A. Baylor, M.G.F. Foortes and P.M. O'Bryan, J. Physiol.214, 265 (1971).

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Authors and Affiliations

  1. Department of Biophysics, Laboratorium voor Algemene Natuurkunde, Rijksuniversiteit Groningen, Groningen, The Netherlands

    H. Muijser

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  1. H. Muijser
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Additional information

Acknowledgments. I am grateful to Dr D.G. Stavenga who inspired me to start the design. I thank P. Cuperus for stimulating discussions and A.J.Th. Liebrand for the construction of the amplifier. This work was supported financially by the Netherlands Organisation for the Advancement of Pure Research (Z.W.O.).

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Muijser, H. A micro-electrode amplifier with an infinite resistance current source for intracellular measurements of membrane potential and resistance changes under current clamp. Experientia 35, 912–913 (1979). https://doi.org/10.1007/BF01955145

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  • DOI: https://doi.org/10.1007/BF01955145

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