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Plasma prostaglandin levels in fed and starved lean, normal and obese women

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Summary

The plasma obtained from fed and starved lean, normal and obese women was estimated, by a radio-immunoassay method, for prostaglandins, owing to their implication in the regulation of adipose tissue lipolysis and the development of obesity. No significant differences were found due to nutritional status or body-build. However, a significantly higher plasma concentration of prostaglandins of the E-type than of the F-type, was found consistently. The very low levels of prostaglandins observed (a range of 0.10–0.15 ng ml−1 for E-type and a range of 0.05–0.07 ng ml−1 for the F-type) may be due, in part, to the activity of a plasmatic prostaglandin metabolizing system.

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Author notes

  1. P. B. Curtis-Prior

    Present address: Department of Biology, Unit for metabolic Diseases, Synthélabo-L.E.R.S., 31 Avenue Paul-Vaillant Couturier, F-92220, Bagneux, France

Authors and Affiliations

  1. Research Department, The Marie Curie Memorial Foundation, Oxted, Surrey, England

    P. B. Curtis-Prior, M. Jenner, M. Smethurst & J. W. Woodward

  2. General Practicioner Unit, Granville Road, Sidcup, Kent, England

    P. B. Curtis-Prior, M. Jenner, M. Smethurst & J. W. Woodward

Authors
  1. P. B. Curtis-Prior
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  2. M. Jenner
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  3. M. Smethurst
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  4. J. W. Woodward
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Additional information

Acknowledgments. The authors are grateful to Dr D.C. Williams for his support and encouragement and to the Upjohn Company for the generous gift of standard prostaglandins.

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Curtis-Prior, P.B., Jenner, M., Smethurst, M. et al. Plasma prostaglandin levels in fed and starved lean, normal and obese women. Experientia 35, 911–912 (1979). https://doi.org/10.1007/BF01955144

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