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125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures

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Summary

125I-Insulin initially localizes to the plasma membrane of isolated rat hepatocytes but is subsequently internalized and preferentially associates with lysosomal structures. In the present study, we show that this preferential association to lysosomes occurs in regions of the cell rich in lysosomal and Golgi structures.

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Literatur

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Author notes

  1. P. Freychet & A. Le Cam

    Present address: Department of Experimental Medicine, INSERM U145, Nice, France

Authors and Affiliations

  1. Institute of Histology and Embryology, Geneva University School of Medicine, CH-1211, Geneva 4, Switzerland

    J. -L. Carpentier, P. Gorden, P. Freychet, A. Le Cam & L. Orci

Authors
  1. J. -L. Carpentier
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  2. P. Gorden
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  3. P. Freychet
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  4. A. Le Cam
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  5. L. Orci
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Additional information

This work was performed while Dr Gorden was visiting professor of the Institute of Histology and Embryology, University of Geneva, Geneva, Switzerland.

This work was supported by grant No. 3.120.77 from Swiss National Science Foundation. We thank M.M. Sidler-Ansermet, O. Jerotic and N. Maalaoui for their valuable help.

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Carpentier, J.L., Gorden, P., Freychet, P. et al. 125I-Insulin is preferentially internalized in regions of the hepatocytes rich in lysosomal and Golgi structures. Experientia 35, 904–906 (1979). https://doi.org/10.1007/BF01955140

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  • DOI: https://doi.org/10.1007/BF01955140

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