, Volume 35, Issue 7, pp 897–898 | Cite as

Appearance of growth-inhibiting activity (G1 chalone) during ontogenetic development of rat and chick epidermis in vivo and in vitro

  • S. Bertsch
  • F. Marks


A comparative study was carried out between the stage of embryonic development of epidermis and its content of growth-inhibitory activity (G1 chalone). Injections of aqueous extracts from keratinized fetal rat or chick embryo epidermis led to a depression of DNA-synthesis in adult mouse epidermis, whereas extracts from undifferentiated epidermis did not contain such an activity.


Depression Embryonic Development Aqueous Extract Adult Mouse Chick Embryo 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


  1. 3.
    T. Weiss and J. L. Kavanau, J. gen. Physiol.41, 1 (1957).Google Scholar
  2. 4.
    O. H. Iversen, Acta path. microbiol. scand, suppl.,148, 91 (1961).Google Scholar
  3. 5.
    W. S. Bullough, Biol. Rev.37, 307 (1962).Google Scholar
  4. 6.
    H. Hennings, K. Elgjo and C. H. Iversen, Virchows Arch. B Zellpath.4, 45 (1969).Google Scholar
  5. 7.
    F. Marks, Hoppe Seyler's Z. physiol. Chem.352, 1273 (1971).Google Scholar
  6. 8.
    W. Hondius-Boldingh and E. B. Laurence, Eur. J. Biochem.5, 191 (1968).Google Scholar
  7. 9.
    K. Elgjo, O. D. Laerum and W. Edgehill, Virchows Arch. B. Zellpath.8, 277 (1971).Google Scholar
  8. 10.
    F. W. Bauer and Ch. M. A. Kuyper, Dermatologica144, 332 (1972).Google Scholar
  9. 11.
    F. Marks, Natl Cancer Inst. Monogr.38, 79 (1973).Google Scholar
  10. 12.
    S. Cohen, Devl Biol.12, 394 (1965).Google Scholar
  11. 13.
    S. Bertsch and F. Marks, Nature252, 517 (1974).Google Scholar
  12. 14.
    F. Marks, Hoppe Seyler's Z. physiol. Chem.356, 1989 (1975).Google Scholar
  13. 15.
    S. Bertsch and F. Marks, Cancer Res.34, 3283 (1974).Google Scholar
  14. 16.
    K. Elgjo and H. Hennings, Virchows Arch. B Zellpath.7, 1 (1971).Google Scholar
  15. 17.
    L. Krieg, I. Kühlmann and F. Marks, Cancer Res.34, 3135 (1974).Google Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • S. Bertsch
    • 1
  • F. Marks
    • 1
  1. 1.German Cancer Research CenterInstitute of BiochemistryHeidelbergFederal Republic of Germany

Personalised recommendations