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A new synthesis ofβ-fluoroaspartic acid

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Summary

β-Fluoroaspartic acid, a new amino acid, was synthesized by a diazotization of diaminosuccinic acid in liquid hydrogen fluoride.

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Literatur

  1. For example; T. Iwasaki, Y. Urabe, Y. Ozaki, M. Miyoshi and K. Matsumoto, J. chem. Soc.1976, 1019; and related references cited therein.

  2. D.C. Klein, K.L. Kirk, J.L. Weller, T. Oka, A. Parfitt and I.S. Owens, Molec. Pharmac.12, 720 (1976).

    CAS  Google Scholar 

  3. J. Kollonitsch, L. Barash, F.M. Kahan and H. Kropp, Nature243, 346 (1973).

    Article  CAS  PubMed  Google Scholar 

  4. V. Tolman and K. Vereš, Colln Czech. chem. Commun.32, 4460 (1967).

    Article  CAS  Google Scholar 

  5. H. Gershon, M.W. McNeil and E.D. Bergmann, J. med. Chem.16, 1407 (1973).

    Article  CAS  PubMed  Google Scholar 

  6. M. Hudlický, Tetrahedron Lett.1960, 21; Colln Czech. chem. Commun.26, 1414 (1961).

  7. H. Lettré and U. Wölcke, Liebigs Ann. Chem.708, 75 (1967).

    Article  Google Scholar 

  8. J. Kollonitsch, S. Marburg and L.M. Perkins, J. org. Chem.40, 3107, 3808 (1975); J. Kollonitsch and L. Barash, J. Am. chem. Soc.98, 5591 (1976).

    Article  Google Scholar 

  9. U-H. Dolling, A.W. Douglas, E.J.J. Grabowski, E.F. Schoenewaldt, P. Sohar and M. Sletzinger, J. org. Chem.43, 1634 (1978).

    Article  CAS  Google Scholar 

  10. K.L. Kirk and L.A. Cohen, J. Am. chem. Soc.95, 4619 (1973).

    Article  CAS  PubMed  Google Scholar 

  11. H. Gershon, L. Shanks and D.D. Clarke, J. pharm. Sci.67, 715 (1978).

    Article  CAS  PubMed  Google Scholar 

  12. Recently,β,β-difluoroaspartic acid was synthesized; J.J.M. Hageman, M.J. Wanner, G-J. Koomen and U.K. Pandit, J. med. Chem.20, 1677 (1977).

    Article  CAS  PubMed  Google Scholar 

  13. A.K. Bose, K.G. Das and P.T. Funke, J. org. Chem.29, 1202 (1964).

    Article  CAS  Google Scholar 

  14. This amino acid has become a useful intermediate of 5-fluorouracil; own unpublished data.

  15. S. Yamada, M. Taniguchi and K. Koga, Tetrahedron Lett.1969, 25.

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Synthesis of Amino Acids and Related Compounds, part 21.—Part 20: Y. Ozaki, S. Maeda, M. Miyoshi and K. Matsumoto, Synthesis, 216 (1979).

We would like to acknowledge Dr I. Chibata for his encouragement in this work.

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Matsumoto, K., Ozaki, Y., Iwasaki, T. et al. A new synthesis ofβ-fluoroaspartic acid. Experientia 35, 850–851 (1979). https://doi.org/10.1007/BF01955104

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