Summary
The influence of spatial configuration on intensity, onset, and duration of anesthetic effect has been observed in some carbanilate local anesthetics of fixed conformation. Synthesis of the carbanilates is described.
Literatur
DeJong, R.H., Local anesthetics. C. C. Thomas, Springfield 1977.
Beneš, L., Borovanský, A., and Kopáčová, L., Archs Pharm.305 (1972) 648.
Beneš, L., Linhart, M., Borovansky, A., and Kopáčová, L., Cslká. Farm.25 (1976) 317.
Beneš, L., Habilitation theses. FaFUK, Bratislava 1975.
Beneš, L., Borovanský, A., and Kopáčová, L., Arzneimittel-Forsch.19 (1969) 1902.
Beneš, L., Tichý, M., Švec, P., Kozlovský, J., Štefek, M., and Borovanský, A., Eur. J. med. Chem.14 (1979) 283.
Pešák, M., Kopecký, F., Čelechovský, J., Beneš, L., and Borovanský, A., Pharmazie31 (1976) 24.
Boots, M., and Boots, S.G., J. Pharm. Sci.58 (1969) 553.
Borne, R.F., Clark, C.R., and Holbrook, J.M., J. med. Chem.16 (1973) 853.
Weinstein, S., and Holness, N.J., J. Am. chem. Soc.77 (1955) 5562.
Eliel, E.L., and Lukach, C.A., J. Am. chem. Soc.79 (1957) 5986.
Sicher, J., Šipoš, F., and Tichý, M., Colln Czech. chem. Commun.26 (1961) 847.
Borovanský, A., Hartl, J., and Kopáčová, L., Čslká Farm.20 (1971) 10.
Paterson, J.G., and Hamilton, J.T., Archs int. Pharmacodyn. Ther.183 (1970) 369.
Paton, W.D.M., J. Physiol., Lond.127 (1955) 40P.
Büchi, J., Grundlagen der Arzneimittelforschung und der synthetischen Arzneimittel. Birkhäuser, Basel-Stuttgart 1963.
Löfgren, N., Studies on local anesthetics. Hoeggström, Stockholm 1948.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Beneš, L., Štolc, S., Bauer, V. et al. Conformation and local anesthetic activity of carbanilates. Experientia 38, 1348–1349 (1982). https://doi.org/10.1007/BF01954944
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01954944