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Effect of gentamycin on insulin release and45Ca net uptake by isolated islets

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Summary

In isolated islets, gentamycin reduced both the45Ca net uptake and insulin release induced by glucose, but failed to inhibit the insulin secretion provoked by the combination of Ba2+ and theophylline. This indicates that the inhibitory effect of gentamycin is due to a reduction of Ca2+ entry into B-cells instead of to a harmful effect upon the integrity of the effector system, responsible for the extrusion of the insulin containing granules.

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Literatur

  1. Wright, J.M., and Collier, B., J. Pharmac. exp. Ther.200 (1977) 576.

    CAS  Google Scholar 

  2. Adams, R., and Durrett, L.R., J. clin. Invest.62 (1978) 241.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Pimenta de Morais, I., Corrado, A.P., and Suarez-Kurtz, G., Archs int. Pharmacodyn.231 (1978) 317.

    CAS  Google Scholar 

  4. Malaisse, W.J., Israel J. med. Sci.8 (1972) 244.

    CAS  PubMed  Google Scholar 

  5. Lacy, P.E., and Kostianovsky, M., Diabetes16 (1967) 35.

    Article  CAS  PubMed  Google Scholar 

  6. Desbuquois, B., and Aurbach, G.D., J. clin. Endocr. Metab.33 (1971) 732.

    Article  CAS  PubMed  Google Scholar 

  7. Malaisse-Lagae, F. and Malaisse, W.J., Endocrinology88 (1971) 72.

    Article  CAS  PubMed  Google Scholar 

  8. Henquin, J.C. and Lambert, A.E., Am. J. Physiol.228 (1975) 1669.

    Article  CAS  PubMed  Google Scholar 

  9. Malaisse, W.J., Hutton, J.C., Sener, A., Levy, J., herchuelz, A., Devis, G., and Somers, G., J. Membrane Biol.38 (1978) 193.

    Article  CAS  Google Scholar 

  10. Hellman, B., Sehlin, J., and Taljedal, I.-B., J. Physiol.254 (1976) 639.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Boschero, A.C., Delattre, E., and Santos, M.L., Horm. Metab. Res.13 (1981) 531.

    Article  CAS  PubMed  Google Scholar 

  12. Hales, C.N., and Milner, R.D.G., J. Physiol.199 (1968) 177.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Somers, G., Devis, G., Van Obberghen, E., and Malaisse, W.J., Pflügers Arch.365 (1976) 21.

    Article  CAS  PubMed  Google Scholar 

  14. Malaisse, W.J., Sener, A., and Herchuelz, A., in: Treatment of Early Diabetes, p. 85. Eds R.A. Camerini-Davalos and B. Hanover. Plenum Press, New York 1979.

    Chapter  Google Scholar 

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Author notes

  1. E. Delattre

    Present address: Departamento de Ciências Fisiológicas, Centro de Ciências Biológicas, Universidade Estadual de Londrina, 86100, Londrina, PR, Brazil

Authors and Affiliations

  1. Departamento de Fisiologia e Biofísica, I. Biologia, UNICAMP, 13.100, Campinas, S.P., Brazil

    E. Delattre, M. L. Santos & A. C. Boschero

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  1. E. Delattre
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  2. M. L. Santos
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  3. A. C. Boschero
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Additional information

Supported by a Grant (No. 79/1872) from the São Paulo State Research Foundation (FAPESP), Brazil.

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Delattre, E., Santos, M.L. & Boschero, A.C. Effect of gentamycin on insulin release and45Ca net uptake by isolated islets. Experientia 38, 1320–1321 (1982). https://doi.org/10.1007/BF01954926

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  • DOI: https://doi.org/10.1007/BF01954926

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