, Volume 38, Issue 11, pp 1301–1309 | Cite as

Antidepressant drugs can slow or dissociate circadian rhythms

  • Anna Wirz-Justice
  • Iain C. Campbell
Full Papers


The circadian rest-activity cycle of female hamsters was lengthened by chronic administration of the monoamineoxidase inhibitor antidepressant drug clorgyline. Chronic treatment with clorgyline or the tricyclic antidepressant drug imipramine also induced dissociation of circadian activity rhythm components. Thus these drugs may be added to the very small group of substances (including the prophylactic antidepressant and antimanic drug lithium) that modify circadian frequency and/or coupling between circadian rhythms.


Lithium Circadian Rhythm Tricyclic Imipramine Chronic Treatment 
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Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • Anna Wirz-Justice
    • 1
  • Iain C. Campbell
    • 1
  1. 1.Clinical Psychobiology BranchNational Institute of Mental HealthBethesdaUSA

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