Experientia

, Volume 38, Issue 11, pp 1301–1309 | Cite as

Antidepressant drugs can slow or dissociate circadian rhythms

  • Anna Wirz-Justice
  • Iain C. Campbell
Full Papers

Summary

The circadian rest-activity cycle of female hamsters was lengthened by chronic administration of the monoamineoxidase inhibitor antidepressant drug clorgyline. Chronic treatment with clorgyline or the tricyclic antidepressant drug imipramine also induced dissociation of circadian activity rhythm components. Thus these drugs may be added to the very small group of substances (including the prophylactic antidepressant and antimanic drug lithium) that modify circadian frequency and/or coupling between circadian rhythms.

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Literatur

  1. 4.
    Pittendrigh, C.S., and Caldarola, P.C., General homeostasis of the frequency of circadian oscillations. Proc. natl Acad. Sci. USA70 (1973) 2697–2701.Google Scholar
  2. 5.
    Richter, C.P., Biological clocks in medicine and psychiatry. Charles C. Thomas, Springfield, Ill. 1965.Google Scholar
  3. 6.
    Morin, L.P., Fitzgerald, K.M., Rusak, B., and Zucker, I., Circadian and neural organization of hamster reproductive rhythms. Psychoneuroendocrinology2 (1977) 73–98.Google Scholar
  4. 7.
    Takahashi, J.S., and Manaker, M., Interaction of estradiol and progesterone: effects on circadian locomotor rhythm of female golden hamsters. Am. J. Physiol.239 (Regulat. integr. comp. Physiol.8) (1980) R497-R504.Google Scholar
  5. 8.
    Daan, S., Damassa, D., Pittendrigh, C. S., and Smith, E.R., An effect of castration and testosterone replacement on a circadian pacemaker in mice (Mus musculus). Proc. natl Acad. Sci. USA72 (1975) 3744–3747.Google Scholar
  6. 9.
    Turek, F.W., McMillan, J.P., and Menaker, M., Melatonin: effects on the circadian locomotor rhythm of sparrows. Science194 (1976) 1441–1443.Google Scholar
  7. 10.
    Beasley, L., and Nelson, R., Thyroid gland influences the period of hamster circadian oscillations. Experientia38 (1982) 870–871.Google Scholar
  8. 11.
    Kamgar-Parsi, B., Wehr, T.A., and Gillin, J.C., Successful treatment of human non-24-hour sleep-wake syndrome. Submitted for publication.Google Scholar
  9. 12.
    Wirz-Justice, A., Groos, G.A., and Wehr, T.A., The neuropharmacology of circadian timekeeping in mammals, in: Vertebrate Circadian Systems: Structure and Physiology. Eds J. Aschoff, S. Daan, and G.A. Groos, Springer, Berlin, Heidelberg 1982, in press.Google Scholar
  10. 13.
    Daan, S., and Pittendrigh, C.S., A functional analysis of circadian pacemakers in nocturnal rodents. III. Heavy water and constant light: homeostasis of frequency? J. comp. Physiol.106 (1976) 267–290.Google Scholar
  11. 14.
    Zatz, M., and Herkenham, M.A., Intraventricular carbachol mimics the phase-shifting effect of light on the circadian rhythm of wheel-running activity. Brain Res.212 (1981) 234–238.Google Scholar
  12. 15.
    Zatz, M., and Brownstein, M.J., Injection ofa-bungarotoxin near the suprachiasmatic nucleus blocks the effects of light on nocturnal pineal enzyme activity. Brain Res.213 (1981) 438–442.Google Scholar
  13. 16.
    Wirz-Justice, A., The effects of lithium on the circadian system, in: Basic Mechanisms in the Action of Lithium, pp. 249–258. Eds H.D. Lux, J.B. Aldenhoff, H.M. Emrich. Excerpta Medica, Amsterdam 1982.Google Scholar
  14. 17.
    Wehr, T.A., and Goodwin, F.K., Biological rhythms and psychiatry, in: American Handbook of Psychiatry, Vol. 7, 2nd edn, pp. 46–74. Eds S. Arieti and H.K.H. Brodie. Basic Books, New York 1981.Google Scholar
  15. 18.
    Wehr, T.A., and Wirz-Justice, A., Circadian rhythm mechanisms in affective illness and in antidepressant drug action. Pharmacopsychiatry15 (1982) 31–39.Google Scholar
  16. 19.
    Daan, S., and Pittendrigh, C.S., A functional analysis of circadian pacemakers in nocturnal rodents. II. The variability of phase response curves. J. comp. Physiol.106 (1976) 253–266.Google Scholar
  17. 20.
    Morgan, N., Vaughn, W., Rasband, W., Wehr, T.A., and Wirz-Justice, A., A computer-based system for collection and analysis of circadian rest-activity data. Experientia38 (1982) 1296–1301.Google Scholar
  18. 21.
    Theeuwes, F., and Yum, S.I., Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations. Ann. Biomed. Engng4 (1976) 343–353.Google Scholar
  19. 22.
    Campbell, I.C., Robinson, D.S., Lovenberg, W., and Murphy, D.L., The effects of chronic regimens of clorgyline and pargyline on monoamine metabolism in the rat brain. J. Neurochem.32 (1979) 49–55.Google Scholar
  20. 23.
    Sokolove, P.G., and Bushnell, W.N., The chi-square periodogram: its utility for analysis of circadian rhythms. J. theor. Biol.72 (1978) 131–160.Google Scholar
  21. 24.
    Pittendrigh, C.S., and Daan, S., A functional analysis of circadian pacemakers in noctural rodents. V. Pacemaker structure: a clock for all seasons. J. comp. Physiol.106 (1976) 333–355.Google Scholar
  22. 25.
    Johnstone, J.P., Some observations upon a new inhibitor of monoamine oxidase in brain tissue. Biochem. Pharmac.17 (1968) 1285–1297.Google Scholar
  23. 26.
    Edwards, D.J., and Malsbury, C.W., Characteristics of monoamine oxidases in rat brain and other organs of the golden hamster. Biochem. Pharmac.27 (1978) 959–963.Google Scholar
  24. 27.
    Aschoff, J., personal communication.Google Scholar
  25. 28.
    Wirz-Justice, A., Wehr, T.A., Goodwin, F.K., Kafka, M.S., Naber, D., Marangos, P.J., and Campbell, I.C., Antidepressant drugs slow circadian rhythms in behaviour and brain neurotransmitter receptors. Psychopharmac. Bull.16 (1980) 45–47.Google Scholar
  26. 29.
    Aschoff, J., The phase-angle difference in circadian periodicity, in: Circadian Clocks, pp. 263–276. Ed. J. Aschoff. North-Holland, Amsterdam 1965.Google Scholar
  27. 30.
    Rommelspacher, H. von, Bade, P., Bludau, J., and Strauss, S., Hemmung der Monoamineoxidase und Tag-Nacht-Rhythmus: Korrelation zwischen physiologischen und biochemischen Parametern. Arzneimittel-Forsch.26 (1976) 1078–1080.Google Scholar
  28. 31.
    Craig, C., Tamarkin, L., Garrick, N., and Wehr, T.A., Longterm and short-term effects of clorgyline (a monoamineoxidase type A inhibitor) on locomotor activity and on pineal melatonin in the hamster, in: Abstract No. 229.14, Society for Neuroscience 11th Annual Meeting, 1981.Google Scholar
  29. 32.
    Mason, R., personal communication.Google Scholar
  30. 33.
    Wirz-Justice, A., Kafka, M.S., Naber, D., and Wehr, T.A., Circadian rhythms in rat brain α-andβ-adrenergic receptors are modified by chronic imipramine. Life Sci.27 (1980) 341–347.Google Scholar
  31. 34.
    Wirz-Justice, A., Kafka, M.S., Naber, D., Campbell, I.C., Marangos, P.J., Tamarkin, L., and Wehr, T.A., Clorgyline delays the phase-position of circadian neurotransmitter receptor rhythms. Brain Res.241 (1982) 115–122.Google Scholar
  32. 35.
    Wirz-Justice, A., Antidepressant drugs: effects on the circadian system, in: Circadian Rhythms in Psychiatry. Eds T.A. Wehr, and F.K. Goodwin. Boxwood Press, Los Angeles 1982, in press.Google Scholar
  33. 36.
    Wehr, T.A., Wirz-Justice, A., Goodwin, F.K., Duncan, W., and Gillin, J.C., Phase advance of the sleep-wake cycle as an antidepressant. Science206 (1979) 710–713.Google Scholar
  34. 37.
    Wirz-Justice, A., and Wehr, T.A., Uncoupling of circadian rhythms in hamsters and man, in: Sleep 1980, pp. 64–72. Ed. W.P. Koella. Karger, Basel 1980.Google Scholar
  35. 38.
    Wehr, T.A., Goodwin, F.K., Wirz-Justice, A., Craig, C., and Breitmaier, J., 48-Hour sleep-wake cycles in manic-depressive illness: naturalistic observations and sleep deprivation experiments. Archs gen. Psychiat.39 (1982) 559–565.Google Scholar
  36. 39.
    Remé, C., and Wirz-Justice, A., Disk shedding and autophagy in rat retina: antidepressant drug modifies retinal circadian rhythms. Suppl. Invest. Ophthalmol.22 (1982) 140.Google Scholar
  37. 40.
    Wehr, T.A., Lewy, A.J., Wirz-Justice, A., Craig, C., and Tamarkin, L., Antidepressants and a circadian rhythm phase-advance hypothesis of depression, in: Brain Neurotransmitters and Hormones, pp. 263–276. Eds R. Collu, J.R. Ducharme, A. Barbeau and G. Tolis. Raven Press, New York 1982.Google Scholar
  38. 41.
    Morimasa, T., Wirz-Justice, A., Kräuchi, K., and Feer, H., Chronic methamphetamine phase delays rat circadian rhythms. XIII international congress of the International Society of Psychoneuroendocrinology, Tübingen 1982; abstract.Google Scholar
  39. 42.
    Bodman, K. von, Die Wirkung von Pharmaka auf Kurzzeitschätzung und circadiane Periodik von Säugetieren. Z. vergl. Physiol.68 (1970) 276–292.Google Scholar
  40. 43.
    Groos, G.A., and Mason, R., An electrophysiological study of the rat's suprachiasmatic nucleus: a locus for the action of antidepressants. J. Physiol., Lond.330 (1982) 40 P.Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • Anna Wirz-Justice
    • 1
  • Iain C. Campbell
    • 1
  1. 1.Clinical Psychobiology BranchNational Institute of Mental HealthBethesdaUSA

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