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Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects

Experientia volume 45, pages 132–134 (1989)Cite this article

Summary

Hemoglobin is widely used as an inhibitor of EDRF effects. Hemoglobin contracts pig coronary arteries in vitro. However, during this contraction, effects of substance P and bradykinin which act via the EDRF are not inhibited. This means that the hemoglobin contraction is not caused by inhibition of the EDRF. This contraction is caused by a substance released from the endothelium, and by eicosanoïds released from the smooth muscles.

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Affiliations

  1. Département de Biologie Animale, Université de Genève, 3, place de l'Université, CH-1211, Genéve 4, (Switzerland)

    J. -L. Bény, P. C. Brunet & V. Van der Bent

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  1. J. -L. Bény
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  2. P. C. Brunet
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  3. V. Van der Bent
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Bény, J.L., Brunet, P.C. & Van der Bent, V. Hemoglobin causes both endothelium-dependent and endothelium-independent contraction of the pig coronary arteries, independently of an inhibition of EDRF effects. Experientia 45, 132–134 (1989). https://doi.org/10.1007/BF01954846

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  • DOI: https://doi.org/10.1007/BF01954846

Key words

  • Coronary artery
  • oxyhemoglobin
  • endothelium
  • EDRF
  • electrophysiology
  • eicosanoïds