Abstract
A 16-year-old girl, diagnosed 1 year previously as having Sydenham chorea, was found to have systemic lupus erythematosus according to the American Rheumatism Association criteria. She now presented with pulmonary emboli and renal involvement and responded to immunosuppressive and anticoagulant therapy. The high levels of anticardiolipin antibodies returned to normal along with the clinical symptoms.
Conclusion
We suggest that anticardiolipin antibodies are relevant to the development of chorea and thrombo-embolic complications and that these auto-antibodies should be sought for in similar cases.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
Abbreviations
- APL :
-
Antiphospholipid antibodies
- SLE :
-
Systemic lupus erythematosus
References
Asherson RA, Derksen RHWM, Bouma BN, et al (1987) Chorea in SLE and “lupus-like” disease: association with antiphospholipid antibodies. Semin Arthritis Rheum 16: 253–259
Herd JK, Medhi M, Uzendoski DM, Saldivar VA (1978) Chorea associated with Systemic Lupus Erythematosus: report of 2 cases and review of literature. Pediatrics 61: 308–315
Ishii Y, Nagasawa K, Mayumi T, Niho Y (1990) Clinical importance of persistence of anticardiolipin antibodies in systemic lupus erythematosus. Ann Rheum Dis 49: 387–390
Khamashta MA, Gil A, Ancione B, et al (1988) Chorea in systemic lupus erythematosus: association with antiphospholipid antibodies. Ann Rheum Dis 67: 681–683
Love PE, Santoro SA (1990) Antiphospholipid antibodies: Anticardiolipin and the lupus anticoagulant in SLE and in non-SLE disorders. Ann Int Med 112: 682–698
May KP, West SG, Moulds J, Kotzin BL (1993) Different manifestations of the antiphospholipid antibody syndrome in a family with SLE. Arthritis Rheum 36: 528–533
McHugh NJ, Maymo J, Skinner RP, James I, Maddison PJ (1988) Anticardiolipin antibodies, livedo reticularis and major cerebrovascular and renal disease in SLE. Ann Rheum Dis 47: 110–115
Montes de Oca MA, Babron MC, Bletry O, et al (1991) Thrombosis in SLE: a French collaborative study. Arch Dis Child 66: 713–717
Saatci U, Kocak H, Aysun S, Orhan V (1977) Systemic lupus erythematosus with chorea. Turk J Pediatr 19: 118–121
Triplett DA, Brandt JT, Musgrave KA, Orr CA (1988) The relationship between lupus anticoagulants and antibodies to phospholipid. JAMA 259: 550–554
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Besbas, N., Damargus, I., Ozen, S. et al. Association of antiphospholipid antibodies with systemic lupus erythematosus in a child presenting with chorea: A case report. Eur J Pediatr 153, 891–893 (1994). https://doi.org/10.1007/BF01954739
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01954739