Summary
Poison oak urushiol, a mixture of 3-alk(en)ylcatechol derivatives was found to mediate DNA strand scission in the presence of oxygen and with copper(II) chloride as a catalyst. The reactionis believed to occur via activated reduced oxygen produced during oxidation of the catechol into itso-quinone derivative.
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Scannell, R. T., Barr, J. R., Murty, V. S., Reddy, K. S., and Hecht, S. M., J. Am. chem. Soc.110 (1988) 3650.
Stubbe, J., and Kozarich, J. W., Chem. Rev.87 (1987) 1107.
Rumyantseva, G. V., Weiner, L. M., Frolova, E. I., and Fedorova, O. S., FEBS Lett.242 (1988) 397.
Scannel, R. T., Barr, J. R., Murty, V. S., Reddy, K. S., and Hecht, S. M., J. Am. chem. Soc.110 (1988) 3650.
Gross, M., and Baer, H., Phytochemistry14 (1975) 2263.
Dupuis, G., Br. J. Dermat.101 (1979) 617.
ElSohly, M. A., Adawadkar, P. D., Ma, C.-Y., and Turner, C. E., J. nat. Prod.45 (1982) 532.
Barr, J. R., Murty, V. S., Yamaguchi, K., Singh, S., Smith, D. H., and Hecht, S. M., Chem. Res. Toxic.1 (1988) 204.
Peisach, J. Burger, R. M., and Horwitz, S. B., Oxygenases Oxygen Metab. (1982) 521.
Reynolds, G. W., and Rodriguez, E., Phytochemistry20 (1981) 1365.
Schultz, P. G., Taylor, J. S., and Dervan, P. B., J. Am. chem. Soc.104 (1982) 6861.
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Wasser, C., Silva, F. & Rodriguez, E. Urushiol components as mediators in DNA strand scission. Experientia 46, 500–502 (1990). https://doi.org/10.1007/BF01954246
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DOI: https://doi.org/10.1007/BF01954246