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Experientia

, Volume 46, Issue 5, pp 461–464 | Cite as

Inhibition of in vitro RNA synthesis by hycanthone, oxamniquine and praziquantel

  • L. -J. C. Wong
  • G. -C. Tsao
  • J. I. Bruce
  • S. S. Wong
Research Articles

Summary

The schistosomicides, hycanthone, oxamniquine and praziquantel, were found to inhibit the in vitro RNA synthesis using isolated hamster liver nuclei. Preincubation of the nuclei with these drugs revealed that the inhibitory effect of oxamniquine was irreversible and progressed with time, whereas that of hycanthone and parziquantel was reversible. On the other hand, hycanthone and praziquantel have a high affinity for DNA but oxamniquine does not. The data indicate that the mechanism of inhibition by oxamniquine is different from that of hycanthone and praziquantel.

Key words

Schistosomicides hycanthone oxamniquine praziquantel RNA synthesis drug resistance 

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Copyright information

© Birkhäuser Verlag 1990

Authors and Affiliations

  • L. -J. C. Wong
    • 1
  • G. -C. Tsao
    • 2
  • J. I. Bruce
    • 3
  • S. S. Wong
    • 2
  1. 1.Department of Biological SciencesUniversity of LowellLowellUSA
  2. 2.Department of ChemistryUniversity of LowellLowellUSA
  3. 3.Center for Tropical DiseasesUniversity of LowellLowellUSA

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