Intravenous nicardipine in hypertensive children
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Fourteen hypertensive patients hospitalized in a paediatric intensive care unit were studied to evaluate safety and hypotensive efficacy of intravenous nicardipine. Systolic and diastolic blood pressure significantly decreased 1 h after the beginning of the treatment (1 μg/kg per minute). Mean decrease in systolic blood pressure during the first 24 h was between 9.9% and 13.4% of the initial value. Mean lowering of diastolic blood pressure was between 16.7% and 25.6%. Nicardipine did not significantly affect heart rate with dose of 1 μg/kg per minute. No clinical side-effects were observed. Nicardipine could be a first line drug for the treatment of hypertension in paediatric intensive care units.
Key wordsNicardipine Children Hypertension
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- 5.Casar G, Pool JL, Chelly JE, Barton S, Turlapaty P, Laddu AR (1987) Intravenous nicardipine for treatment of postoperative hypertension. Anesthesiology 67:A141Google Scholar
- 6.Combalbert J, Fabre I, Fabre G, Dalet I, Derancourt J, Cano JP, Maurel P (1989) Metabolism of cyclosporin A: purification and identification of rifampicin-inducible human liver cytochrome P-450 (cyclosporin oxydase) as a product of P450 IIIA gene subfamily. Drug Metab Dispos 17:197–207PubMedGoogle Scholar
- 7.David D, Dubois C, Loria Y (1988) Intravenous nicardipine versus nitroprusside in the treatment of hypertensive crisis following coronary artery bypass surgery: multicentric comparative randomised and open study. European association of cardiothoracic anesthesiologists 3rd meeting, Lyon, France, 8th–10th June 1988Google Scholar
- 9.Higuchi S, Shiobara Y (1989) Metabolic fate of nicardipine hydrochloride, a new vasodilatator, by various species in vitro. Xenobiotica 7:889–896Google Scholar
- 12.Report of second task force on blood pressure control in children (1987) Pediatrics 79:1–25Google Scholar
- 13.Rousseau MF, Pouleur H (1987) Calcium antagonism free of negative inotropic effects? A comparison of intracoronary nicardipine and nifedipine. Circulation 75:304Google Scholar