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Cholinergic components in the gastrin pathway of gastric acid stimulation

Experientia volume 36, pages 973–974 (1980)Cite this article

Summary

In the isolated whole stomach of the mouse, cimetidine and atropine appear to be specific antagonists of histamine- and acetylcholine-induced stimulation of parietal cells. Interactions were demonstrated between cimetidine and gastrin, atropine and gastrin, respectively. In addition to a histaminergic pathway of gastrin stimulation, a cholinergic part, probably postganglionic, can be taken into consideration.

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Affiliations

  1. Department of Pharmacology and Toxicology, Heumann-Pharma, Heideloffstrasse 18-28, D-8500, Nürnberg, (Federal Republic of Germany)

    I. Szelenyi

Authors
  1. I. Szelenyi
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Additional information

Acknowledgments. I am indebted to Miss G.B. Bishop for her help with the English translation.

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Szelenyi, I. Cholinergic components in the gastrin pathway of gastric acid stimulation. Experientia 36, 973–974 (1980). https://doi.org/10.1007/BF01953827

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  • DOI: https://doi.org/10.1007/BF01953827

Keywords

  • Histamine
  • Cimetidine
  • Atropine
  • Gastric Acid
  • Parietal Cell