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Modification of radiation response by agents that elevate the intracellular c-AMP level

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Summary

A study has been made of the effects of drugs known to elevate c-AMP level on radiation-induced damage in thymocytes. The test used was the ability of the cells to exclude dye. β-receptor stimulation and phosphodiesterase inhibition were found to induce radioresistance. The possible importance of the plasma membrane in connection with cytoplasmic factors is briefly discussed.

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Literatur

  1. S. Lehnert, Radiat. Res.62, 107 (1975).

    Article  CAS  PubMed  Google Scholar 

  2. S. Lehnert, Radiat. Res.64, 394 (1975).

    Article  CAS  PubMed  Google Scholar 

  3. T.L. Pazdernik and E. Uyeki, Int. J. Radiat. Biol.26, 331 (1974).

    CAS  Google Scholar 

  4. J.F. Scaife, Int. J. Radiat. Biol.19, 191 (1971).

    CAS  Google Scholar 

  5. N.L. Oleinick, E.N. Brewer and R.C. Rustad, Int. J. Radiat. Biol.33, 69 (1978).

    CAS  Google Scholar 

  6. F. Ojeda, M. Flores and H. Folch, Z. Naturforsch.34C, 888 (1979).

    Article  CAS  Google Scholar 

  7. A. Pektau and W.A. Chelack, Biochim. biophys. Acta433, 445 (1976).

    Article  Google Scholar 

  8. F. Ojeda, P. Peña and H. Folch, Experientia33, 605 (1977).

    Article  CAS  PubMed  Google Scholar 

  9. T. Alper, 2nd Symp. Microdositometry Stresa Euratom EUR 4452, p.5. 1970.

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Authors and Affiliations

  1. Department of Physics and Department of Experimental Medicine, Universidad Austral de Chile, Valdivia, Chile

    F. Ojeda, G. Aravena & H. Folch

Authors
  1. F. Ojeda
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  2. G. Aravena
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  3. H. Folch
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Additional information

Supported by International Atomic Energy Agency contract 2175/RB, PNUD Grant 102/77 and UACH Grant S-79-2.

We thank Dr E. Ortega for the irradiation facilities.

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Ojeda, F., Aravena, G. & Folch, H. Modification of radiation response by agents that elevate the intracellular c-AMP level. Experientia 36, 957–958 (1980). https://doi.org/10.1007/BF01953816

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  • DOI: https://doi.org/10.1007/BF01953816

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