Summary
Under in vitro experimental conditions in which insulin increases adipose tissue lipoprotein lipase, cyclic GMP or dibutyryl cyclic GMP has no effect on this enzyme in rat adipose tissue fragments, or on either the intra- or extracellular forms of this enzyme in isolated fat cells. These results do not support the involvement of cyclic GMP in the insulin-stimulation of lipoprotein lipase in adipose tissue.
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Literatur
N. Vydelingum, A.H. Kissebah and V. Wynn, Horm. Metab. Res.10, 38 (1978).
G. Illiano, G.P.E. Tell, M.I. Siegel and P. Cuatrecasas, Proc. natl Acad. Sci. USA70, 2443 (1973).
M.R. Salaman and D.S. Robinson, Biochem. J.99, 640 (1966).
P. Nilson-Ehle, A.S. Garfinkel and M.C. Scholtz, Biochim. biophys. Acta431, 147 (1976).
D.M. Kornhauser and M. Vaughan, Biochim. biophys. Acta380, 97 (1975).
Y. Giudicelli, D. Provin, R. Pecquery and R. Nordmann, Biochim. biophys. Acta450, 358 (1976).
W.W. Umbreit, R.H. Burris and J.F. Stauffer, in: Manometric Techniques, p. 132. Burgess, Minneapolis 1964.
T. Minemura, W.W. Lacy and O.B. Crofford, J. biol. Chem.245, 3872 (1970).
H. Greten and B. Walter, FEBS Lett.35, 36 (1973).
V.P. Dole and H. Meinertz, J. biol. Chem.235, 2595 (1960).
T.F. Kelley, J. Lipid Res.9, 799 (1968).
D.S. Robinson and D.R. Wing, in: Adipose tissue, Regulation and Metabolic Functions, p.41. Ed. B. Jeanrenaud and D. Hepp. Academic Press, New York, London 1970.
Y. Giudicelli, B. Agli, D. Brulle and R. Nordmann, FEBS Lett.83, 225 (1977).
J. Levilliers, J. Pairault, F. Lecot, A. Tournemolle and M.H. Laudat, Eur. J. Biochem.88, 323 (1978).
S. Hynie, G. Krishna and B.B. Brodie, J. Pharmac. exp. Ther.153, 90 (1966).
D.R. Wing and D.S. Robinson, Biochem. J.109, 841 (1968).
G.A. Robinson, R.W. Butcher and E.W. Sutherland, in: Cyclic AMP, p.97. Academic Press, New York, London 1971.
R.H. Eckel, W.Y. Fujimoto and J.D. Brunzell, Biochem. biophys. Res. Commun.84, 1069 (1978).
T. Asakawa, J. Ruiz and R.J. Ho, Proc. natl Acad. Sci. USA75, 2684 (1978).
P. Ashby, D.P. Bennett, I.M. Spencer and D.S. Robinson, Biochem. J.176, 865 (1978).
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Acknowledgments. This work was supported by grants from the Institut National de la Santé et de la Recherche Médicale (INSERM), the Université René Descartes (Paris V) and the École Pratique des Hautes-Etudes (3e Section).
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Bourdeaux, AM., Giudicelli, Y., Rebourcet, MC. et al. Evidence against the involvement of cyclic GMP in the insulin-stimulation of lipoprotein lipase activity in fat cells. Experientia 36, 913–914 (1980). https://doi.org/10.1007/BF01953789
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DOI: https://doi.org/10.1007/BF01953789