, Volume 36, Issue 8, pp 906–908 | Cite as

Separation of modulator-dependent protein kinase (type I) from cyclic GMP-dependent protein kinase in mouse testes

  • W. N. Kuo
  • K. M. Foggie
  • L. P. Liu


A new type of enzyme, modulator-dependent protein kinase (type I) (M-PKI), was successfully isolated from the cytosol fraction of mouse testes. It was eluted slightly after the peak of cyclic GMP-dependent protein kinase (G-PK) by Sephadex G-200 gel filtration. Unlike either cyclic AMP-dependent protein Kinase (A-PK) or G-PK, its maximal activity depended exclusively on the presence of crude protein kinase modulators (PKM) or partially purified stimulatory modulator (PKMs).


Enzyme Filtration Protein Kinase Cytosol Crude Protein 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • W. N. Kuo
    • 1
  • K. M. Foggie
    • 1
  • L. P. Liu
    • 1
  1. 1.Division of Science and MathematicsBethune-Cookman CollegeDaytona BeachUSA

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