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Methoxyphenylethylamines as substrates for type A and type B monoamine oxidase

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Summary

4-Methoxyphenylethylamine was found to be a specific substrate for type B monoamine oxidase (MAO) in rat brain mitochondria, whereas 3,4-dimethoxyphenylethylamine was common for both types of MAO. These results suggest that O-methylation in the para-position increases the preference of the substrate for type B MAO, while a methoxy-group in the meta-position contributes to the substance being a type A substrate.

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Literatur

  1. J. P. Johnston, Biochem. Pharmac.17, 1285 (1968).

    Article  CAS  Google Scholar 

  2. H.-Y. T. Yang and N. H. Neff, J. Pharmac. exp. Ther.187, 365 (1973).

    CAS  Google Scholar 

  3. H.-Y. T. Yang and N. H. Neff, J. Pharmac. exp. Ther.189, 733 (1974).

    CAS  Google Scholar 

  4. M. D. Houslay and K. F. Tipton, Biochem. J.139, 645 (1974).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. O. Suzuki, M. Oya and Y. Katsumata, Biochem. Pharmac.28, 2682 (1979).

    Article  CAS  Google Scholar 

  6. O. Suzuki, H. Hattori, Y. Katsumata and M. Oya, Life Sci.25, 1231 (1979).

    Article  CAS  PubMed  Google Scholar 

  7. O. Suzuki, Y. Katsumata, M. Oya and T. Matsumoto, Biochem. Pharmac.28, 2327 (1979).

    Article  CAS  Google Scholar 

  8. O. Suzuki, T. Matsumoto, M. Oya and Y. Katsumata, Experientia35, 1283 (1979).

    Article  CAS  PubMed  Google Scholar 

  9. J. Knoll and K. Magyar, in: Advances in Biochemical Psychopharmacology, vol. 5, p. 393. Ed. E. Costa and M. Sandler. Raven Press, New York 1972.

    Google Scholar 

  10. G. G. Guilbault, P. J. Brignac, Jr, and M. Juneau, Analyt. Chem.40, 1256 (1968).

    Article  CAS  Google Scholar 

  11. S. H. Snyder and E. D. Hendley, J. Pharmac. exp. Ther.163, 386 (1968).

    CAS  Google Scholar 

  12. O. Suzuki, E. Noguchi and K. Yagi, Brain Res.135, 305 (1977).

    Article  CAS  PubMed  Google Scholar 

  13. O. Suzuki, Y. Katsumata, M. Oya and T. Matsumoto, Biochem. Pharmac.28, 953 (1979).

    Article  CAS  Google Scholar 

  14. O. Suzuki, H. Hattori, M. Oya, Y. Katsumata and T. Matsumoto, Life Sci.25, 1843 (1979).

    Article  CAS  PubMed  Google Scholar 

  15. B. Ekstedt, Biochem. Pharmac.25, 1133 (1976).

    Article  CAS  Google Scholar 

  16. R. F. Squires, in: Advances in Biochemical Psychopharmacology, vol. 5, p. 355. Ed. E. Costa and M. Sandler. Raven Press, New York 1972.

    Google Scholar 

  17. O. Suzuki, M. Oya, Y. Katsumata and M. Asano, Experientia35, 167 (1979).

    Article  CAS  PubMed  Google Scholar 

  18. O. Suzuki, H. Hattori, M. Oya and Y. Katsumata, Biochem. Pharmac.29, 603 (1980).

    Article  Google Scholar 

  19. J. A. Roth and K. Feor, Biochem. Pharmac.72, 1606 (1978).

    Article  Google Scholar 

  20. J. M. Saavedra, in: Essays in Neurochemistry and Neuropharmacology, vol. 1, p. 1. Ed. M. B. H. Youdim, W. Lovenberg, D. F. Sharman and J. R. Lagnado. John Wiley & Sons, London 1977.

    Google Scholar 

  21. M. Takesada, Y. Kakimoto, I. Sano and Z. Kaneko, Nature199, 203 (1963).

    Article  CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Legal Medicine, Hamamatsu University School of Medicine, 431-31, Hamamatsu, Japan

    O. Suzuki, T. Matsumoto, Y. Katsumata & M. Oya

  2. Division of Oncology, First Department of Surgery and Department of Legal Medicine, Nagoya University School of Medicine, 466, Nagoya, Japan

    O. Suzuki, T. Matsumoto, Y. Katsumata & M. Oya

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  1. O. Suzuki
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  2. T. Matsumoto
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  3. Y. Katsumata
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  4. M. Oya
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Suzuki, O., Matsumoto, T., Katsumata, Y. et al. Methoxyphenylethylamines as substrates for type A and type B monoamine oxidase. Experientia 36, 895–897 (1980). https://doi.org/10.1007/BF01953778

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  • DOI: https://doi.org/10.1007/BF01953778

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