, Volume 36, Issue 2, pp 259–260 | Cite as

The effect of pinealectomy on serum progesterone and oestradiol levels during the last stage of pregnancy in rats

  • I. Nir
  • N. Hirschmann


Pinealectomy leads to significantly higher levels of progesterone (on days 19 and 20 of gestation) and oestradiol (on days 21 and 22) in the serum of pregnant rats. These results indicate that during the last phase of pregnancy the pineal gland may be modifying the levels of gonadal hormones, although not affecting the sequence of the physiological events.


Progesterone Oestradiol Physiological Event Pineal Gland Oestradiol Level 
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  1. 1.
    L.C. Ellis, Am. Zool.16, 67 (1976).Google Scholar
  2. 2.
    K.P. Minneman and R.J. Wurtman, A. Rev. Pharmac. Toxic.16, 33 (1976).Google Scholar
  3. 3.
    I. Nir, N. Hirschmann, G. Goldhaber and J. Shani, Neuroendocrinology28, 44 (1979).Google Scholar
  4. 4.
    G. Gibori and J.S. Richards, Endocrinology102, 767 (1978).Google Scholar
  5. 5.
    P.A. Kelly, R.P. Shiu, M.C. Robertson and H.G. Friesen, Endocrinology96, 1187 (1975).Google Scholar
  6. 6.
    T.F. Ogle and J.I. Kitay, J. Endocr.74, 89 (1977).Google Scholar
  7. 7.
    I. Nir, in: The Pineal Gland, p. 225. Ed. I. Nir, R.J. Reiter and R.J. Wurtman, Springer-Verlag, Wien 1978.Google Scholar
  8. 8.
    G. Pepe and I. Rothchild, Endocrinology91, 1380 (1972).Google Scholar

Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • I. Nir
    • 1
  • N. Hirschmann
    • 1
  1. 1.Department of Pharmacology and Experimental TherapeuticsHebrew University, Schools of Medicine and PharmacyJerusalem(Israel)

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