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Diabetic syndrome in the Chinese hamster induced with monosodium glutamate

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Summary

Neuronal necrosis in the arcuate and ventromedial hypothalamus regions is easily induced in 1-day-old Chinese hamsters by the administration of monosodium glutamate (MSG). New-born Chinese hamsters injected with MSG showed no sign of obesity, even when grown up, but apparently developed a diabetic syndrome.

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Authors and Affiliations

  1. Division of Laboratory Animal Science, Animal Research Center, Tokyo Medical College, 6-1-1 Shinjuku, Shinjuku-Ku, 160, Tokyo, Japan

    K. Komeda, M. Yokote & Y. Oki

  2. Tokai Regional Fisheries Research Laboratory, Arasaki, 238-03, Yokosuka, Japan

    K. Komeda, M. Yokote & Y. Oki

  3. Department of Physiological Chemistry, Nippon Veterinary and Zootechnical College, 180, Musashino-Shi, Tokyo, Japan

    K. Komeda, M. Yokote & Y. Oki

Authors
  1. K. Komeda
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  2. M. Yokote
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  3. Y. Oki
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Additional information

This work was supported in part by the grant 349024 from the Ministry of Education, Science and Culture, Japan.

Acknowledgment. The authors are grateful to Dr K. Suzuki, Institute of Medical Science, Tokyo University, for his kind and valuable suggestion.

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Komeda, K., Yokote, M. & Oki, Y. Diabetic syndrome in the Chinese hamster induced with monosodium glutamate. Experientia 36, 232–234 (1980). https://doi.org/10.1007/BF01953751

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  • DOI: https://doi.org/10.1007/BF01953751

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