Diabetic syndrome in the Chinese hamster induced with monosodium glutamate

Summary

Neuronal necrosis in the arcuate and ventromedial hypothalamus regions is easily induced in 1-day-old Chinese hamsters by the administration of monosodium glutamate (MSG). New-born Chinese hamsters injected with MSG showed no sign of obesity, even when grown up, but apparently developed a diabetic syndrome.

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This work was supported in part by the grant 349024 from the Ministry of Education, Science and Culture, Japan.

Acknowledgment. The authors are grateful to Dr K. Suzuki, Institute of Medical Science, Tokyo University, for his kind and valuable suggestion.

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Komeda, K., Yokote, M. & Oki, Y. Diabetic syndrome in the Chinese hamster induced with monosodium glutamate. Experientia 36, 232–234 (1980). https://doi.org/10.1007/BF01953751

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Keywords

  • Obesity
  • Glutamate
  • Monosodium
  • Monosodium Glutamate
  • Hypothalamus Region