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Vascular reactivity in hypertension: Altered effect of ouabain

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Summary

Ouabain inhibits the relaxing effect of Ca2+ (but not of Mn2+) on contractile responses in tail artery strips isolated from spontaneously hypertensive and normotensive rats. The magnitude of ouabain inhibition was greater in vascular strips from hypertensive rats suggesting a significant difference in basic membrane function in hypertensive vascular smooth muscle.

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Authors and Affiliations

  1. Department of Physiology, University of Michigan Medical School, 48109, Ann Arbor, Michigan, USA

    R. C. Webb & D. F. Bohr

Authors
  1. R. C. Webb
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  2. D. F. Bohr
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Additional information

These studies were supported by National Heart, Lung, and Blood Institute grants HL-03765 and HL-18575-02-03. R.C. Webb is a Postdoctoral Research Fellow of the Michigan Heart Association.

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Webb, R.C., Bohr, D.F. Vascular reactivity in hypertension: Altered effect of ouabain. Experientia 36, 220–222 (1980). https://doi.org/10.1007/BF01953743

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  • DOI: https://doi.org/10.1007/BF01953743

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