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Determination of odour affinities based on the dose-response relationships of the frog's electro-olfactogram

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Summary

Electro-olfactograms (EOG's) recorded from the frog's olfactory epithelium for 11 substances were used to calculate dissociation constants which in turn serve as an index for the affinity between odorant and receptor site. These constants were calculated with and without a correction for the odour partition between water and air. For a homologous series of 7 n-alcohols these values decrease up to 1-heptanol. The dose-response relationships were based on the peaks of the EOG's since the peak/plateau-ratio was concentration-dependent for some of the substances.

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References

  1. D. Ottoson, Acta physiol. scand.43, 167 (1958).

    Article  CAS  PubMed  Google Scholar 

  2. L.M. Beidler, J. gen. Physiol.38, 133 (1954).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. W. Jakinowich, Brain Res.110, 481 (1976).

    Article  Google Scholar 

  4. D. Tucker, J. gen. Physiol.43, 453 (1963).

    Article  Google Scholar 

  5. T.M. Poynder, J. Soc. cosm. Chem.25, 183 (1974).

    CAS  Google Scholar 

  6. T.M. Poynder, in: Transduction Mechanisms in Chemoreception, p. 241. Ed. T.M. Poynder. Information Retrieval Ltd, London 1974.

    Google Scholar 

  7. H.E.J. Wijnands and J.J. van Gelder, Neth. J. Zool.26, 414 (1976).

    Article  Google Scholar 

  8. Handbook of Chemistry and Physics, 56th ed. CRC Press, Cleveland, Ohio, 1975/76.

  9. D. Ottoson, Acta physiol. scand.35, Suppl. 122, 1 (1956).

    Google Scholar 

  10. P. Duyvesteyn, in: Olfaction and Taste VI, p. 482. Ed. J. LeMagnen and P. MacLeod. Information Retrieval Ltd, London, Washington 1978.

    Google Scholar 

  11. S. Higashino, S.F. Takagi and M. Yajima, Jap. J. Physiol.11, 530 (1961).

    Article  CAS  Google Scholar 

  12. P.H. Punter and E.P. Köster, in: Olfaction and Taste VI, p. 71. Ed. J. LeMagnen and P. MacLeod. Information Retrieval Ltd, London and Washington 1978.

    Google Scholar 

  13. J.T. Davies and F.H. Taylor, Biol. Bull.117, 222 (1959).

    Article  Google Scholar 

  14. H. Stephen and T. Stephen, Solubilities of Organic and Inorganic Compounds. Pergamon Press, Oxford, New York 1963.

    Google Scholar 

  15. T. Ueda and Y. Kobatake, J. Membrane Biol.34, 351 (1977).

    Article  CAS  Google Scholar 

  16. P.H. Punter and B.Ph.M. Menco, in preparation.

  17. P. Seeman, S. Roth and H. Schneider, Biochim. biophys. Acta,225, 171 (1971).

    Article  CAS  PubMed  Google Scholar 

  18. C.R. Kahn, J. Cell Biol.70, 261 (1976).

    Article  CAS  PubMed  Google Scholar 

  19. B.P.M. Menco, L.M. Schoonhoven and J. Visser, Proc. K. ned. Akad. Wet. Series C77, 157 (1974).

    CAS  Google Scholar 

  20. R.H. Cagan and W.N. Zeiger, Proc. natl Acad. Sci. USA75, 4679 (1978).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. R.J. Cherry, G.H. Dodd and D. Chapman, Biochim. biophys. Acta211, 409 (1970).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Psychologisch Laboratorium, Rijksuniversiteit Utrecht, Varkenmarkt 2, NL-3511 BZ, Utrecht, The Netherlands

    W. Senf, B. Ph. M. Menco, P. H. Punter & P. Duyvesteyn

Authors
  1. W. Senf
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  2. B. Ph. M. Menco
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  3. P. H. Punter
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  4. P. Duyvesteyn
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Additional information

This work was supported by Z.W.O. grant number 12-24-12 of the Dutch Government.

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Senf, W., Menco, B.P.M., Punter, P.H. et al. Determination of odour affinities based on the dose-response relationships of the frog's electro-olfactogram. Experientia 36, 213–215 (1980). https://doi.org/10.1007/BF01953738

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