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Changes in blood-brain permeability resulting from d-amphetamine, 6-hydroxydopamine and pimozide measured by a new technique

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Summary

A new technique is described for measurement of diffusion across the blood-brain barrier using intraventricularly administered68Ga-EDTA, and determining loss from the brain with a scintillation camera. Repeated injections via permanent cannulas showed that the diffusion half-time was reduced to 50% of control values after intraventricular d-amphetamine and 6-hydroxydopamine; pimozide had no effect.

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Author notes

  1. U. Braun & Gisela Braun

    Present address: Pharmakologisches Institut der Universität, D-53, Bonn, FRG

Authors and Affiliations

  1. Donner Laboratory, University of California, 94720, Berkeley, California, USA

    U. Braun, Gisela Braun & Th. Sargent III

Authors
  1. U. Braun
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  2. Gisela Braun
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  3. Th. Sargent III
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Additional information

Acknowledgment. This work was supported by the Division of Biomedical and Environmental Research of the US Department of Energy, and the Deutsche Forschungsgemeinschaft.

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Braun, U., Braun, G. & Sargent, T. Changes in blood-brain permeability resulting from d-amphetamine, 6-hydroxydopamine and pimozide measured by a new technique. Experientia 36, 207–209 (1980). https://doi.org/10.1007/BF01953735

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  • DOI: https://doi.org/10.1007/BF01953735

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