, Volume 38, Issue 8, pp 968–970 | Cite as

Orally administered melatonin stimulates the 3α/β-hydroxysteroid oxidoreductase but not the 5α-reductase in the ventral prostate and seminal vesicles of pinealectomized rats

  • H. -J. Horst
  • A. Buck
  • K. -U. Adam
Specialia Endocrinologica


Pinealectomized rats were treated orally with melatonin (MEL) for 14 days. Prostates and seminal vesicles were investigated for the activity of the δ 4-3-ketosteroid-5α-oxidoreductase (5α-R) and of the 3α/β-hydroxysteroid-oxidoreductase (3α-HSO). The activity of the 3a-HSO was significantly stimulated (p<0.01, Friedman test) when compared to controls. The activity of the 5α-R did not change significantly.


Melatonin Seminal Vesicle Oxidoreductase Friedman Test Ventral Prostate 
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  1. 2.
    J.A. Kastin, S. Viosca, R.M.G. Nair, A.V. Schally and M.C. Miller, Endocrinology91, 1323 (1972).Google Scholar
  2. 3.
    J.E. Martin, J.N. Engel and D.C. Klein, Endocrinology100, 675 (1975).Google Scholar
  3. 4.
    J.A. Kamberi, R.S. Mical and J.C. Porter, Endocrinology88, 1288 (1971).Google Scholar
  4. 5.
    A.A. MacPhee, F.E. Cole and B.F. Rice, J. clin. Endocr. Metab.40, 688 (1975).Google Scholar
  5. 6.
    L.C. Ellis and R.L. Urry, Physiologist15, 125 (1972).Google Scholar
  6. 7.
    F. Peat and G.A. Kinson, Steroids17, 251 (1971).Google Scholar
  7. 8.
    T.F. Ogle and J.I. Kitay, Neuroendocrinology23, 113 (1977).Google Scholar
  8. 9.
    H.-J. Horst and K.-U. Adam, Horm. Metab. Res., in press (1981).Google Scholar
  9. 10.
    J. Kuszak and M. Rodin, Experientia33, 283 (1977).Google Scholar
  10. 11.
    P.K. Grover and W.D. Odell, J. Steroid Biochem.6, 1373 (1975).Google Scholar
  11. 12.
    R. Moore and J.D. Wilson, J. biol. Chem.247, 958 (1972).Google Scholar
  12. 13.
    L. Buriĉ, H. Becker, C. Petterson and K.-D. Voigt, Acta endocr., Copenh.69, 153 (1972).Google Scholar
  13. 14.
    M. Friedman, J. Am. statist. Ass.32, 675 (1937).Google Scholar
  14. 15.
    S.M. Reppert and D.C. Klein, Endocrinology102, 582 (1978).Google Scholar
  15. 16.
    K.-U. Adam, doctoral thesis, Hamburg 1981.Google Scholar
  16. 17.
    J.T. Isaacs, J.R. McDermott and D.S. Coffey, Steroids33, 675 (1979).Google Scholar
  17. 18.
    H.-J. Horst, J. Steroid Biochem.11, 945 (1979).Google Scholar
  18. 19.
    N. Bruchovsky and G. Lieskovsky, J. Endocr.80, 289 (1979).Google Scholar
  19. 20.
    G.A. Kinson and F. Peat, Life Sci.10, 259 (1971).Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • H. -J. Horst
    • 1
  • A. Buck
    • 1
  • K. -U. Adam
    • 1
  1. 1.Abteilung Klinische Chemie2. Medizinische UniversitätsklinikHamburg 20Germany

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