Experientia

, Volume 38, Issue 8, pp 951–953 | Cite as

Reinforcement with naloxone of N-n-propylnorapomorphine (NPA) capability for stimulating male rat copulatory behavior

  • Francesca Ferrari
  • G. Baggio
Specialia Pharmacologica

Summary

Naloxone at a dose of 2 mg·kg−1, which per se did not significantly alter the copulatory pattern of sexually active adult male rats, did significantly reduce the intromission frequency as well as latency to ejaculation when administered before a low and inactive dose of N-n-propylnorapomorphine (0.5 μg·kg−1).

Keywords

Naloxone Copulatory Behavior Copulatory Pattern Intromission Frequency Inactive Dose 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1.
    A. Bertolini, S. Genedani and M. Castelli, Experientia34, 771 (1978).Google Scholar
  2. 2.
    G.L. Gessa, E. Paglietti and B. Pellegrini Quarantotti Science204, 203 (1979).Google Scholar
  3. 3.
    R.M. Quock, Life Sci.20, 2005 (1977).Google Scholar
  4. 4.
    R.M. Quock and T.B. Welsh, J. Pharm. Pharmac.33, 111 (1981).Google Scholar
  5. 5.
    P.M. Adams, R. Beauchamp and C. Alston, Life Sci.28, 629 (1980).Google Scholar
  6. 6.
    A. Benassi Benelli, F. Ferrari and B. Pellegrini Quarantotti, Archs int. Pharmacodyn. Thér.242, 241 (1979).Google Scholar
  7. 7.
    F. Ferrari and G. Baggio, Proc. 2nd Capo Boi Conf. Neurosci., Capo Boi (Cagliari), June 7–10 (1981), in press.Google Scholar
  8. 8.
    P. Johnston and J.M. Davidson, Horm. Behav.3, 345 (1972).Google Scholar
  9. 9.
    D.A. Dewsbury, Eur. J. Pharmac.17, 221 (1972).Google Scholar
  10. 10.
    A. Benassi Benelli and F. Ferrari, Experientia35, 645 (1979).Google Scholar
  11. 11.
    D.I. Margolin and B.Y. Moon, J. Neurol. Sci.43, 13 (1979).Google Scholar
  12. 12.
    B.Y. Moom, J.J. Feigenbaum, P.E. Carson and H.L. Klawans, Eur. J. Pharmac.61, 71 (1980).Google Scholar
  13. 13.
    R.E. Whalen, B.B. Gorzalka and J.F. DeBold, in: Sexual behavior: pharmacology and biochemistry, p. 33. Eds M. Sandler and G.L. Gessa. Raven Press, New York 1975.Google Scholar
  14. 14.
    H. Lal, G. Gianutsos and S.K. Puri, Life Sci.17, 29 (1975).Google Scholar
  15. 15.
    E. Eidelberg and R. Erspamer, J. Pharmac. exp. Ther.192, 50 (1975).Google Scholar
  16. 16.
    S.N. Deyo, R.M. Swift and R.J. Miller, Proc. natl Acad. Sci.76, 3006 (1979).Google Scholar

Copyright information

© Birkhäuser Verlag 1982

Authors and Affiliations

  • Francesca Ferrari
    • 1
  • G. Baggio
    • 1
  1. 1.Institute of Pharmacology, Chair of Pharmacology and PharmacognosyUniversity of ModenaModenaItaly

Personalised recommendations