, Volume 44, Issue 7, pp 608–610 | Cite as

Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon

  • W. Clauss
  • J. E. Dürr
  • R. Krattenmacher
  • H. Hörnicke
  • W. Van Driessche
Short Communications


In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone.

Key words

Rabbit colon in vivo in vitro potential difference isotopes noise analysis sodium transport apical sodium channels plasma aldosterone 


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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • W. Clauss
    • 1
  • J. E. Dürr
    • 2
  • R. Krattenmacher
    • 1
  • H. Hörnicke
    • 2
  • W. Van Driessche
    • 3
  1. 1.Institut für VeterinärphysiologieFreie Universität BerlinBerlin 33 West
  2. 2.Institut für ZoophysiologieUniversität HohenheimStuttgart 70(Federal Republic of Germany)
  3. 3.Laboratorium voor FysiologieK.U.L.Leuven(Belgium)

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