Circadian rhythm of apical Na-channels and Na-transport in rabbit distal colon
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In vivo and in vitro studies showed that electrogenic sodium transport in rabbit distal colon is modulated by aldosterone. It varies in a circadian rhythm; the external synchronizer is the light-dark cycle. The site of regulation was found to be in the apical membrane of colonic epithelial cells, in which the number of conducting sodium-channels is increased by aldosterone.
Key wordsRabbit colon in vivo in vitro potential difference isotopes noise analysis sodium transport apical sodium channels plasma aldosterone
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