Experientia

, Volume 35, Issue 12, pp 1661–1663 | Cite as

Elimination and metabolism of dimethylnitrosamine (DMN) byXenopus laevis and other amphibians

  • R. R. Rao
  • R. H. Clothier
  • R. M. Hodgson
  • M. Balls
Article

Summary

The elimination of (14C)-DMN after i.p. injection intoXenopus was measured, as was the metabolism in vitro of (14C)-DMN by liver fromXenopus and 9 other amphibian species. In view of its rapid elimination from the body and low rate of metabolism byXenopus liver in vitro, DMN is unlikely to be toxic or carcinogenic inXenopus.

Keywords

Amphibian Species Rapid Elimination Dimethylnitrosamine 

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Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • R. R. Rao
    • 1
  • R. H. Clothier
    • 1
  • R. M. Hodgson
    • 1
  • M. Balls
    • 1
  1. 1.Department of Human MorphologyUniversity of Nottingham, Queen's Medical CentreNottingham(England)

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