, Volume 35, Issue 12, pp 1645–1647 | Cite as

Time courses and refractoriness of enhanced vascular permeability induced by histamine, serotonin and bradykinin in synovialis of the rat

  • L. P. Bignold
  • A. W. J. Lykke


Enhanced vascular permeability induced in synovialis of the rat by histamine and serotonin lasts 5–15 min and that induced by bradykinin less than 5 min. Synovialis of the rat becomes refractory to the permeability effects of repeated doses of each of these substances in the hour following initial application.


Permeability Serotonin Histamine Bradykinin Vascular Permeability 
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  1. 3.
    H. R. Schumacher, Ann. rheum. Dis.32, 212 (1973).PubMedGoogle Scholar
  2. 4.
    H. R. Schumacher, Arthritis Rheum.12, 387 (1969).PubMedGoogle Scholar
  3. 5.
    L. P. Bignold and A. W. J. Lykke, Experientia31, 671 (1975).PubMedGoogle Scholar
  4. 6.
    D. M. Grennan, W. Mitchell, W. Miller and I. J. Zeitlin, Br. J. Pharmac.60, 251 (1977).Google Scholar
  5. 7.
    R. S. Cotran, E. R. Suter and G. Majno, Vasc. Dis.4, 107 (1967).PubMedGoogle Scholar
  6. 8.
    D. A. Rowley and E. P. Benditt, J. exp. Med.103, 399 (1956).CrossRefPubMedGoogle Scholar
  7. 9.
    I. A. Oyvin, P. Y. Gaponiuk and I. V. Oyvin, Experientia23, 925 (1967).PubMedGoogle Scholar
  8. 10.
    A. Baumgarten, G. J. H. Melrose and W. J. Vagg, J. Physiol., Lond.208, 669 (1970).Google Scholar
  9. 11.
    M. Greaves and S. Schuster, J. Physiol., Lond.193, 255 (1967).Google Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • L. P. Bignold
    • 1
  • A. W. J. Lykke
    • 1
  1. 1.School of PathologyUniversity of New South WalesKensingtonAustralia

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