, Volume 35, Issue 12, pp 1615–1617 | Cite as

Isometric relaxation in rat myocardium: Load dependence and influence of caffeine

  • C. Poggesi
  • L. Ricciardi
  • C. Reggiani
  • R. Minelli


When caffeine plus calcium is added to the perfusing medium, isometric relaxation of rat myocardium is no longer affected by length changes occurring during the twitch. The dependence of isometric relaxation on the initial muscle length is still present and more pronounced after caffeine addition.


Calcium Caffeine Length Change Muscle Length Perfuse Medium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    D.L. Brutsaert, N.M. De Clerck, M.A. Goethals and P.R. Housmans, J. Physiol.283, 469 (1978).PubMedGoogle Scholar
  2. 2.
    A.J. Brady, Fedn Proc.24, 1410 (1965).Google Scholar
  3. 3.
    R.L. Kaufmann, R.M. Bayer and C. Harnasch, Pflügers Arch.332, 96 (1972).CrossRefGoogle Scholar
  4. 4.
    B.R. Jewell and D.R. Wilkie, J. Physiol.152, 30 (1960).PubMedGoogle Scholar
  5. 5.
    A.S. Bahler, Am. J. Physiol.220, 1983 (1971).PubMedGoogle Scholar
  6. 6.
    B. Johansson and P. Hellstrand, Acta physiol. scand.93, 167 (1975).PubMedGoogle Scholar
  7. 7.
    L. Blayney, H. Thomas, J. Muir and A. Henderson, Circulation Res.43, 520 (1978).PubMedGoogle Scholar
  8. 8.
    J.R. Blinks, C.B. Olson, B.R. Jewell and P. Braveny, Circulation Res.30, 367 (1972).PubMedGoogle Scholar
  9. 9.
    C.L. Gibbs, Physiol. Rev.58, 174 (1978).PubMedGoogle Scholar
  10. 10.
    F.J. Julian and M.R. Sollins, Circulation Res.37, 299 (1975).PubMedGoogle Scholar
  11. 11.
    R. Bodem and E.H. Sonnenblick, Am. J. Physiol.228, 250 (1975).PubMedGoogle Scholar
  12. 12.
    W.W. Parmley and E.H. Sonnenblick, Am. J. Physiol.216, 1084 (1969).PubMedGoogle Scholar
  13. 13.
    D.K. Hill, J. Physiol.221, 161 (1972).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • C. Poggesi
    • 1
  • L. Ricciardi
    • 1
  • C. Reggiani
    • 1
  • R. Minelli
    • 1
  1. 1.Institute of Human PhysiologyUniversity of PaviaPavia(Italy)

Personalised recommendations