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Experientia

, Volume 35, Issue 12, pp 1565–1567 | Cite as

Genetic polymorphisms and intrauterine development. Evidence of decreased heterozygosity in light-for-dates human newborn babies

  • E. Bottini
  • F. Gloria-Bottini
  • P. Lucarelli
  • A. Polzonetti
  • F. Santoro
  • A. Varveri
Article

Summary

In 2 independent samples of low-birth-weight infants the proportion of females and homozygotes for a series of polymorphic systems was higher in light-for-dates than in preterm babies. The observation seems to give support to the hypothesis that homozygosity for ‘normal’ polymorphisms may decrease in general intrauterine growth rate. Since it is known that survival rate is strongly related to birth weight, a correlation between growth retardation and homozygosity may have a major role in the maintenance of such polimorphisms.

Keywords

Growth Rate Survival Rate Birth Weight Growth Retardation Genetic Polymorphism 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

  1. 1.
    G. B. Johnson, Science184, 28 (1974).PubMedGoogle Scholar
  2. 2.
    B. Wallace, Evolution29, 193 (1975).Google Scholar
  3. 3.
    H. Harris and D. A. Hopkinson, Handbook of enzyme electrophoresis in human genetics. North-Holland Publ., Amsterdam 1976.Google Scholar
  4. 4.
    S. Campbell, in: Fetal Physiology and Medicine, The basis of Perinatology, p. 271. Ed. R. W. Beard and P. W. Nathanielsz. W. B. Saunders, London-Philadelphia 1976.Google Scholar
  5. 5.
    W. R. Klecka, in: SPSS, Statistical Package for the Social Science, 2nd edn. Ed. N. H. Nie, C. H. Hull, J. G. Jenkins, K. Steinbrenner and D. H. Bent. McGraw-Hill Book Company, 1975.Google Scholar
  6. 6.
    A. E. Beer and R. E. Billingham, Adv. Immunobiol.14, 1 (1971).Google Scholar
  7. 7.
    R. R. Gordon, Br. med. J.1, 1313 (1977).PubMedGoogle Scholar

Copyright information

© Birkhäuser Verlag 1979

Authors and Affiliations

  • E. Bottini
    • 1
    • 2
  • F. Gloria-Bottini
    • 1
    • 2
  • P. Lucarelli
    • 1
    • 2
  • A. Polzonetti
    • 1
    • 2
  • F. Santoro
    • 1
    • 2
  • A. Varveri
    • 1
    • 2
  1. 1.Dept. of Genetics and Computer CenterUniversity of CamerinoCamerino(Italy)
  2. 2.Center of Evolutionary Genetics of CNR and ‘Bambino Gesù’ Hospital for Sick ChildrenRome(Italy)

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