Experientia

, Volume 32, Issue 10, pp 1313–1315 | Cite as

The effect of thiazol-4-ylmethoxyamine, a histidine decarboxylase inhibitor, on the development of morphine tolerance and physical dependance in mice

  • Koon-Sea Hui
Pharmacologica

Summary

A new histidine decarboxylase inhibitor, thiazol-4-ylmethoxyamine (TMA), injected into mice in a dose of 100 mg/kg i.p. 48 h before the implantation of a morphine-containing pellet, inhibited the development of morphine tolerance and physical dependence.

Keywords

Morphine Histidine Physical Dependance Morphine Tolerance Histidine Decarboxylase 

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 3.
    H. H. Loh, F. H. Shen andE. L. Way, Biochem. Pharmac.18, 2711 (1969).Google Scholar
  2. 4.
    M. P. Feinberg andJ. Cochin, Biochem. Pharmac.21, 3082 (1972).Google Scholar
  3. 5.
    J. P. Green,Handbook of Neurochemistry (Ed.A. Lajtha; Plenum Press, New York 1970), vol. 4, p. 221.Google Scholar
  4. 6.
    K. S. Hui andM. B. Roberts, IRCS med. Sci.2, 1688 (1974).Google Scholar
  5. 7.
    K. S. Hui andM. B. Roberts, Life Sci.17, 891 (1975).Google Scholar
  6. 8.
    C. L. Wong andM. B. Roberts, Agents Actions5, 476 (1975).Google Scholar
  7. 9.
    I thank Dr.Glenn H. Hamor, University of Southern California, for a supply of TMA as the dihydrochloride.Google Scholar
  8. 10.
    M. K. Menon, W. G. Clark andD. Aures, Life Sci.10, 1097 (1971).Google Scholar
  9. 11.
    K. S. Hui andM. B. Roberts, J. Pharm. Pharmac.27, 569 (1975).Google Scholar
  10. 12.
    L. S. Harris andA. K. Pierson, J. Pharmac. exp. Ther.143, 141 (1964).Google Scholar
  11. 13.
    Naloxone hydrochloride, Endo Laboratories Inc. N.Y., USA.Google Scholar
  12. 14.
    E. L. Way, H. H. Loh andF. H. Shen, J. Pharmac. exp. Ther.167, 1 (1969).Google Scholar
  13. 15.
    H. Kupferberg, A. Burkhalter andE. L. Way, J. Pharmac. exp. Ther.145, 247 (1964).Google Scholar
  14. 16.
    R. Håkanson, A.-L. Rönnberg andK. Sjölund, Analyt. Biochem.47, 356 (1972).Google Scholar
  15. 17.
    J. T. Litchfield, Jr. andF. Wilcoxon, J. Pharmac. exp. Ther.96, 99 (1949).Google Scholar

Copyright information

© Birkhäuser Verlag 1976

Authors and Affiliations

  • Koon-Sea Hui
    • 1
  1. 1.Department of Pharmacology, Faculty of MedicineUniversity of Hong KongHong Kong

Personalised recommendations