Skip to main content
SpringerLink
Log in

Further characterization of sulfated homopolysaccharides as anti-HIV agents

  • Research Articles
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Fucoidan and dextran sulfate showed anti-HIV activities against mononuclear cells from AIDS patients, and they abrogated HIV reverse transcriptase (RT) activity by interacting with the HIV envelope in the membranes of target cells. Furthermore, they showed a synergistic effect with azidothymidine (AZT).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

Literature

  1. Mizumoto, K., Sugawara, I., Ito, W., Kodama, T., Hayami, M. and Mori, S., Jpn. J. exp. Med.58 (1988) 145.

    CAS  PubMed  Google Scholar 

  2. Boyum, A., Scand. J. clin. Lab. Invest.21 (1968) 97.

    Article  Google Scholar 

  3. Daniel, M. D., Letvin, N. L., King, N. W., Kannagi, M., Sehegal, P. K., and Hunt, R. D., Science228 (1985) 1201.

    Article  CAS  PubMed  Google Scholar 

  4. Kikukawa, R., Koyanagi, Y., Harada, S., Kobayashi, N., Hatanaka, M., and Yamamoto, N., J. Virol.57 (1986) 1159.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Lifson, J., Contre, S., Huang, E., and Engleman, E., J. exp. Med.164 (1986) 2101.

    Article  CAS  PubMed  Google Scholar 

  6. Sugawara, I., and Ishizaka, S., Cell Immun.68 (1982) 402.

    Article  CAS  Google Scholar 

  7. Sugawara, I., and Ishizaka, S., Cell. Immun.74 (1982) 162.

    Article  CAS  Google Scholar 

  8. Sugawara, I., Ishizaka, S., and Moller, G., Immunobiology163 (1982) 527.

    Article  CAS  PubMed  Google Scholar 

  9. Palacios, R., Sugawara, I., and Fernandez, C., J. Immun.128 (1982) 621.

    Article  CAS  PubMed  Google Scholar 

  10. Sugawara, I., and Ishizaka, S., Microbiol. Immun.28 (1984) 831.

    Article  CAS  Google Scholar 

  11. Sugawara, I., and Ishizaka, S., Agents Actions13 (1983) 354.

    Article  CAS  PubMed  Google Scholar 

  12. Kojima, T., Tabata, K., Hirata, A., and Sugawara, I., Agric. biol. Chem.50 (1986) 1635.

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Pathology, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, 108, Minato-ku, Tokyo, Japan

    I. Sugawara & S. Mori

  2. Department of Internal Medicine, Institute of Medical Science, The University of Tokyo, Shirokanedai 4-6-1, 108, Minato-ku, Tokyo, Japan

    S. Kimura & K. Shimada

  3. Research Laboratory, Taito Co., Higashishiriike-Shinmachi, Nagata-ku, 653, Kobe, Japan

    W. Itoh

Authors
  1. I. Sugawara
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. W. Itoh
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. S. Kimura
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. Mori
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. K. Shimada
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Sugawara, I., Itoh, W., Kimura, S. et al. Further characterization of sulfated homopolysaccharides as anti-HIV agents. Experientia 45, 996–998 (1989). https://doi.org/10.1007/BF01953060

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01953060

Key words

Search

Navigation