Abstract
Wistar albino rats were intravenously injected with 1 ml of an oxyphoretic emulsion of perfluorobutylfurane and killed 3, 7 or 30 days later. Mitochondria isolated from the liver and kidneys of treated rats showed a small decrease in the transmembrane electrical potential and a substantial depression of the rates of both ATP synthesis and ADP-stimulated respiration. These alterations in mitochondrial oxidative phosphorylation appear to be induced by perfluorocarbon and/or tensioactive molecules interacting with hydrophobic cell structures.
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Branca, D., Chiarelli, S.M., Vincenti, E. et al. Alteration of mitochondrial bioenergetics due to intravenous injection of a perfluorocarbon emulsion. Experientia 50, 660–663 (1994). https://doi.org/10.1007/BF01952868
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DOI: https://doi.org/10.1007/BF01952868