Skip to main content

Ultractructural changes in rat mammotropes following incubation with dopamine

Experientia volume 49, pages 836–839 (1993)Cite this article

Abstract

Cultured mammotropes incubated with dopamine for one hour exhibited changes in ultrastructure indicative of actively depressed biosynthetic and secretory activity. Peripheral relocation of rough endoplasmic reticulum appeared to create a barrier to secretory granule release by exocytosis. A decrease in the numbers of secretory granules indicated a decrease in prolactin production and enhanced lysosomal activity.

This is a preview of subscription content, access via your institution.

Access options

Buy single article

Instant access to the full article PDF.

43,34 €

Price includes VAT (Finland)
Tax calculation will be finalised during checkout.

Literature

  1. Talwalker, P. K., Ratner, A., and Meites, J., Am. J. Physiol.205 (1963) 213.

    PubMed  Google Scholar 

  2. Everett, J. W., Endocrinology54 (1972) 685.

    Google Scholar 

  3. Shin, S. H., Neuroendocrinology31 (1980) 375.

    PubMed  Google Scholar 

  4. Lamberts, S. W., and MacLeod, R. M., Physiol. Rev.70 (1990) 279.

    PubMed  Google Scholar 

  5. Brown, G. M., Seeman, P., and Lee, T., Endocrinology99 (1976) 1407.

    PubMed  Google Scholar 

  6. Reifel, C. W. Saunders, S. L., and Shin, S. H., Neuroendocrinology36 (1983) 242.

    PubMed  Google Scholar 

  7. Reifel, C. W., Shin, S. H., and Saunders, S. L., Neuroendocrinology40 (1985) 438.

    PubMed  Google Scholar 

  8. Reifel, C. W., Shin, S. H., and Leather, R. A., Cell Tiss. Res.232 (1983) 249.

    Google Scholar 

  9. Ishibashi, T., and Shiino, M., Acta anat.131 (1988) 66.

    PubMed  Google Scholar 

  10. Reynolds, E. J. J. Cell Biol.17 (1963) 208.

    PubMed  Google Scholar 

  11. Cinti, S., Sbarbati, A., Marella, M., and Osculati, F., Anat. Rec.212 (1985) 381.

    PubMed  Google Scholar 

  12. Nogami, H., and Yoshimura, F., Cell Tiss. Res.211 (1980) 1.

    Google Scholar 

  13. Rennels, E. G., McGill, J. R., Kobayashi, K., and Shiino, M., in: The Anterior Pituitary, p. 27. Ed. A. S. Bhatnagar. Raven Press, New York 1983.

    Google Scholar 

  14. Tixier-Vidal, A., in: The Anterior Pituitary, p. 181. Eds A. Tixier-Vidal and M. G. Farquhar. Academic Press, New York 1975.

    Google Scholar 

  15. Farquhar, M. G., in: Subcellular Organization and Function in Endocrine Tissues, p. 79. Eds. H. Heller and K. Lederis. Cambridge University Press, Cambridge 1971.

    Google Scholar 

  16. Farquhar, M. G., Adv. exp. med. Biol.80 (1977) 37.

    PubMed  Google Scholar 

  17. Hausler, A., and Hodel, C., Acta endocr., Suppl.193 (1975) 66.

    Google Scholar 

  18. Rennels, E. G., Blask, E. E., and Warchol, J. B., Gunma Symp. Endocr.13 (1976) 180.

    Google Scholar 

  19. Porter, K. R., and Tucker, J. B., Scient. Am.244 (1981) 56.

    Google Scholar 

  20. Stirling, R. G., and Shin, S. H., Molec. cell. Endocr.70 (1990) 65.

    PubMed  Google Scholar 

  21. Swennen, L., and Denef, C., Endocrinology111 (1982) 398.

    PubMed  Google Scholar 

  22. Schettini, G., Cronin, M. J., and McLeod, R. M., Endocrinology112 (1983) 1801.

    PubMed  Google Scholar 

  23. Nansel, D. D., Gudelsky, G. A., Reymond, M. J., Neaves, W. B., and Porter, J. C., Endocrinology108 (1981) 896.

    PubMed  Google Scholar 

  24. deDuve, C., in: Ciba Foundation Symposium on Lysosomes, p. 1. Eds A. V. S. de Reuck and M. P. Cameron. Little and Brown, Boston 1963.

    Google Scholar 

  25. DeDuve, C., Fedn Proc.23 (1964) 1045.

    Google Scholar 

  26. Smith, R. E., and Farquhar, M. G., J. Cell Biol.31 (1966) 319.

    Google Scholar 

  27. Stokreef, J. C., Reifel, C. W., and Shin, S. H., Cell Tiss. Res.243 (1986) 255.

    Google Scholar 

  28. Reifel, C. W., Shin, S. H., and Stokreef, J. C., Histochemistry91 (1989) 483.

    PubMed  Google Scholar 

Download references

Author information

Affiliations

  1. Department of Anatomy, Queen's University, Kingston, Ontario, Canada

    M. Joneja, C. W. Reifel & M. L. Murphy

  2. Department of Physiology, Queen's University, Kingston, Ontario, Canada

    S. H. Shin

Authors
  1. M. Joneja
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. C. W. Reifel
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. M. L. Murphy
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. S. H. Shin
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Joneja, M., Reifel, C.W., Murphy, M.L. et al. Ultractructural changes in rat mammotropes following incubation with dopamine. Experientia 49, 836–839 (1993). https://doi.org/10.1007/BF01952593

Download citation

  • Received:

  • Accepted:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01952593

Key words

  • Pituitary
  • adenohypohysis
  • mammotrope
  • dopamine
  • prolactin