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External strontium and contractility in single giant muscle fibers of the barnacle

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Summary

Isometric tension and membrane potential in response to electrical stimulation have been studied on single giant muscle fibers of the barnacle upon replacement of external calcium with strontium. Under these conditions, the membrane response showed after the normal peak depolarization, a plateau phase lasting 3–7 sec before repolarization took place, while the force of contraction showed a linear relation with external strontium concentration. A direct action of strontium ions on contractile proteins (namely troponin) can be ruled out in favor of a triggering action on the sarcoplasmic reticulum, which, in turn, leads to calcium release and development of tension.

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Author notes

  1. F. Franciolini

    Present address: Istituto di Biologia Cellulare, Università di Perugia, via Elce di Sotto, I-06100, Perugia, Italy

Authors and Affiliations

  1. Physiological Laboratory, University of Oxford, Parks Road, OX13PT, Oxford, England

    F. Franciolini

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  1. F. Franciolini
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Acknowledgment. I wish to thank Dr C. C. ashley in whose laboratory the research reported in this paper was performed, and Mrs L. M. Castell for invaluable technical assistance. This work was supported by grant No. 106140/048104235 from Consiglio Nazionale delle Ricerche, Italy.

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Franciolini, F. External strontium and contractility in single giant muscle fibers of the barnacle. Experientia 40, 386–388 (1984). https://doi.org/10.1007/BF01952567

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