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Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide

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The sensitivity to the diabetogenic action of triphenyltin hydroxide (TPTOH) was investigated in 5 species of experimental animals. A single oral administration of TPTOH produced marked hyperglycemia and triglyccridemia in rabbits and hamsters, but no evidence of diabetes was found in mice, rats and guinea-pigs. No morphological abnormality was observed in islet tissue from TPTOH-treated hamsters.

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References

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Authors and Affiliations

  1. Department of Hygiene, School of Medicine, Gunma University, 371, Maebashi, Japan

    H. Matsui, O. Wada, S. Manabe, Y. Ushijima & T. Fujikura

  2. Clinical Laboratory, School of Medicine, Gunma University, 371, Maebashi, Japan

    H. Matsui, O. Wada, S. Manabe, Y. Ushijima & T. Fujikura

  3. First Department of Pathology, School of Medicine, Gunma University, 371, Maebashi, Japan

    H. Matsui, O. Wada, S. Manabe, Y. Ushijima & T. Fujikura

Authors
  1. H. Matsui
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  2. O. Wada
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  3. S. Manabe
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  4. Y. Ushijima
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  5. T. Fujikura
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Matsui, H., Wada, O., Manabe, S. et al. Species difference in sensitivity to the diabetogenic action of triphenyltin hydroxide. Experientia 40, 377–378 (1984). https://doi.org/10.1007/BF01952561

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  • DOI: https://doi.org/10.1007/BF01952561

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