Experientia

, Volume 40, Issue 4, pp 371–372 | Cite as

Protection of rat gastric mucosa against ethanol injury by the new synthetic prostaglandin MDL 646

  • G. Pallavicini
  • A. Bardoni
  • A. Profumo
  • A. A. Castellani
  • P. Schiatti
  • A. Glässer
Short Communications

Summary

Oral administration to fasted rats of absolute ethanol produces extensive necrotic lesions of gastric mucosa as well as a massive leakage of proteins and mucus glycoproteins into gastric lumen. When the new synthetic prostaglandin MDL 646, belonging to the PGE1 series, is administered intragastrically (2 or 10 μg/kg) 30 min before ethanol administration, a significant protection of rat gastric mucosa against alcohol injury is observed.

Keywords

Alcohol Prostaglandin Oral Administration PGE1 Gastric Mucosa 

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Copyright information

© Birkhäuser Verlag 1984

Authors and Affiliations

  • G. Pallavicini
    • 1
    • 2
  • A. Bardoni
    • 1
    • 2
  • A. Profumo
    • 1
    • 2
  • A. A. Castellani
    • 1
    • 2
  • P. Schiatti
    • 1
    • 2
  • A. Glässer
    • 1
    • 2
  1. 1.Biochemistry DepartmentUniversity of PaviaPavia(Italy)
  2. 2.Pharmacology Dept.Lepetit Research Labs.Milan(Italy)

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