Skip to main content
SpringerLink
Log in

Carbon tetrachloride modulates the rat hepatic microsomal UDP-glucuronyl transferase activity and membrane fluidity

  • Short Communications
  • Cellular and Molecular Biology, Immunology
  • Published:
Experientia Aims and scope Submit manuscript

Summary

Modulations in rat hepatic microsomal UDP-glucuronyl transferase activity have been observed during carbon tetrachloride (CCl4) poisoning, with a large decrease in the enzyme cooperativity and increase in the membrane fluidity, occurring 30 min after administration. The results strengthen the possibility that an increase in microsomal membrane fluidity may be an early key event in liver injury induced by CCl4.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Literature

  1. Dutton, C.J., and Storey, I.D.E., Biochem. J.57 (1954) 275.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  2. Axelrod, J., Inscoe, J.K., and Tomkins, G.M., Nature179 (1957) 538.

    Article  CAS  PubMed  Google Scholar 

  3. Erickson, R.H., Zakin, D., and Vessey, D.A., Biochemistry17 (1978) 3706.

    Article  CAS  PubMed  Google Scholar 

  4. Pechey, D.T., Graham, A.B., and Wood, G.C., Biochem. J.175 (1978) 115.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Kornbrust, D.J., and Mavis, R.D., Molec. Pharmac.17 (1980) 408.

    CAS  Google Scholar 

  6. Reynolds, E.S., J. Cell Biol.19 (1963) 139.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Deliconstantinos, G., and Ramantanis, G., Biochem. J.212 (1983) 445.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Deliconstantinos, G., Neurochem. Res.8 (1983) 1143.

    Article  CAS  PubMed  Google Scholar 

  9. Deliconstantinos, G., Anastasopoulou, K., and Karayianakos, P., Biochem. Pharmac.32 (1983) 1309.

    Article  CAS  Google Scholar 

  10. Tsakiris, S., and Deliconstantinos, G., Biochem. J.220 (1984) 301.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  11. Deliconstantinos, G., Biochem. J.222 (1984) 825.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Holloway, C.T., and Garfield, S.A., Lipids16 (1981) 525.

    Article  CAS  PubMed  Google Scholar 

  13. Shinitzky, M., and Barenholz, Y., Biochim. biophys. Acta515 (1978) 367.

    Article  CAS  PubMed  Google Scholar 

  14. Farias, R.N., Adv. Lipid Res.17 (1980) 251.

    Article  CAS  PubMed  Google Scholar 

  15. Miller, G.L., Analyt. Chem.31 (1959) 964.

    Article  CAS  Google Scholar 

  16. Tavoloni, N., Jones, M.J.T., Wittman, R., Kiang, C.L., and Berk, P.D., Clinica chim. Acta128 (1983) 209.

    Article  CAS  Google Scholar 

  17. Van Roy, F.P., and Heirwegh, K.P.M., Biochem. J.107 (1968) 507.

    Article  PubMed  PubMed Central  Google Scholar 

  18. Lippiello, P.M., Holloway, C.T., Garfield, S.A., and Halloway, P.W., J. biol. Chem.254 (1979) 2004.

    Article  CAS  PubMed  Google Scholar 

  19. Papahajopoulos, D., Cowden, M., and Kimelberg, H., Biochim. biophys. Acta330 (1973) 8.

    Article  Google Scholar 

  20. Recknagel, R.O., Pharmac. Rev.19 (1967) 145.

    CAS  Google Scholar 

  21. Zakim, D., Goldenberg, J., and Vessey, D.A., Eur. J. Biochem.28 (1973) 59.

    Article  Google Scholar 

  22. Van Blitterswijk, W.J., Van Hoeven, R.P., and Van der Meer, B.W., Biochim. biophys. Acta.644 (1981) 323.

    Article  PubMed  Google Scholar 

  23. Glaumann, H., Bergstrand, R., and Ericsson, J.L.E., J. Cell Biol.64 (1975) 356.

    Article  CAS  PubMed  Google Scholar 

  24. Moore, L., Davenport, G.B., and Landon, E.J., J. biol. Chem.251 (1976) 1197.

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Experimental Physiology, and Department of Experimental Pharmacology, University of Athens, Medical School, GR-115 27, Athens, Greece

    G. Deliconstantinos, M. Mykoniatis & D. Papadimitriou

Authors
  1. G. Deliconstantinos
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. M. Mykoniatis
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. D. Papadimitriou
    View author publications

    You can also search for this author in PubMed Google Scholar

Additional information

Acknowledgments. This work was supported by funds of the University of Athens.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Deliconstantinos, G., Mykoniatis, M. & Papadimitriou, D. Carbon tetrachloride modulates the rat hepatic microsomal UDP-glucuronyl transferase activity and membrane fluidity. Experientia 42, 181–183 (1986). https://doi.org/10.1007/BF01952457

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01952457

Key words

Search

Navigation