Experientia

, Volume 42, Issue 2, pp 157–158 | Cite as

Reduction of high affinity glutamate uptake in rat hippocampus by two polyamine-like toxins isolated from the venom of the predatory waspphilanthus triangulum F

  • J. van Marle
  • T. Piek
  • A. Lind
  • J. van Weeren-Kramer
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology

Summary

Two components of the venom of the predatory waspPhilanthus triangulum F. significantly reduce — to a greater or less extent — the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 μM δ-PTX caused a reduction of 74%, while the other component, β-PTX, at the same concentration, caused a reduction of 18%. Hence the effect of δ-PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that β-PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, β-PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than δ-PTX.

Key words

Glutamate high affinity uptake hippocampus insect toxins β-PTX δ-PTX polyamines 

Literature

  1. 1.
    Piek, T., Kits, K. S., Spanjer, W., van Marle, J., and Van Wilgenburg, H., Neurotoxicology (1985) in press.Google Scholar
  2. 2.
    Van Marle, J., Piek, T., Lind, A., and Van Weeren-Kramer, J., Comp. Biochem. Physiol.79C (1984) 213.Google Scholar
  3. 3.
    Storm-Mathisen, J., in: Glutamate as a Neurotransmitter, p. 43. Eds G. DiChiarra and G. L. Gessa. Raven Press, 1981.Google Scholar
  4. 4.
    Storm-Mathisen, J., Ciba Foundation Symposium58 (new series) (1977) 49.PubMedGoogle Scholar
  5. 5.
    Fonnum, F., J. Neurochem.42 (1984) 1.PubMedGoogle Scholar
  6. 6.
    Fagg, G. E., and Foster, A. C., Neuroscience9 (1983) 701.CrossRefPubMedGoogle Scholar
  7. 7.
    Storm-Mathisen, J., and Iversen, L. L., Neuroscience4 (1979) 1237.CrossRefPubMedGoogle Scholar
  8. 8.
    Taxt, T., and Storm-Mathisen, J., J. Physiol., Paris75 (1979) 677.Google Scholar
  9. 9.
    Taxt, T., and Storom-Mathisen, J., Neuroscience11 (1984) 79.CrossRefPubMedGoogle Scholar
  10. 10.
    Halpain, S., Wieczorek, C. M., and Rainbow, T. C., J. Neurosci.4 (1984) 2247.PubMedGoogle Scholar
  11. 11.
    Law, C. L., Wong, P. C. L., and Fong, W. F., J. Neurochem.42 (1984) 870.PubMedGoogle Scholar
  12. 12.
    Piek, T., Ciba Foundation Symposium88 (1982) 275.Google Scholar

Copyright information

© Birkhäuser Verlag Basel 1986

Authors and Affiliations

  • J. van Marle
    • 1
  • T. Piek
    • 1
  • A. Lind
    • 1
  • J. van Weeren-Kramer
    • 1
  1. 1.Department of PharmacologyUniversity of Amsterdam, Academic Medical CentreAmsterdam(The Netherlands)

Personalised recommendations