, Volume 42, Issue 2, pp 157–158 | Cite as

Reduction of high affinity glutamate uptake in rat hippocampus by two polyamine-like toxins isolated from the venom of the predatory waspphilanthus triangulum F

  • J. van Marle
  • T. Piek
  • A. Lind
  • J. van Weeren-Kramer
Short Communications Biochemistry and Biophysics, Metabolism, Neurobiology, Pharmacology


Two components of the venom of the predatory waspPhilanthus triangulum F. significantly reduce — to a greater or less extent — the high affinity uptake of glutamate in rat hippocampus. A concentration of 10 μM δ-PTX caused a reduction of 74%, while the other component, β-PTX, at the same concentration, caused a reduction of 18%. Hence the effect of δ-PTX on high affinity glutamate uptake in the hippocampus is comparable with its effect on high affinity glutamate uptake in insect neuromuscular junctions. Contrary to our previous findings that β-PTX has no effect on high affinity glutamate uptake in insect glutamatergic terminal axons, however, β-PTX significantly reduces high affinity glutamate uptake in the hippocampus, albeit less effectively than δ-PTX.

Key words

Glutamate high affinity uptake hippocampus insect toxins β-PTX δ-PTX polyamines 


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Copyright information

© Birkhäuser Verlag Basel 1986

Authors and Affiliations

  • J. van Marle
    • 1
  • T. Piek
    • 1
  • A. Lind
    • 1
  • J. van Weeren-Kramer
    • 1
  1. 1.Department of PharmacologyUniversity of Amsterdam, Academic Medical CentreAmsterdam(The Netherlands)

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