, Volume 42, Issue 2, pp 133–134 | Cite as

Muscle proteinase activities during compensatory growth and atrophy

  • D. F. Goldspink
Short Communications Anatomy, Physiology


Specific activities of cathepsins B and D, but not H, increased in both the tenotomized gastrocnemius and functionally overloaded soleus muscles, thus correlating with previously reported increases in protein degradation. Subsequent denervation of the overloaded soleus caused an additive increase in proteolysis, suggesting a possible greater lability of proteins in this muscle.

Key words

Cathepsin B, D and H skeletal muscle tenotomy denervation protein degradation compensatory growth muscle atrophy 


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Copyright information

© Birkhäuser Verlag Basel 1986

Authors and Affiliations

  • D. F. Goldspink
    • 1
  1. 1.Department of PhysiologyThe Queen's University of Belfast, Medical Biology CentreBelfastNorthern Ireland, UK

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