Summary
Rat serum contains natural 1,5-anhydroglucitol. Injected or orally administered 1,5-anhydroglucitol was efficiently reabsorbed by the renal tubuli via a mechanism which had a saturation point at high serum 1,5-anhydroglucitol levels. The compound had a slow turnover rate in the body; its half-life is approximately 3 days. The compound was readily absorbed in the gut when administered orally.
References
Pitkänen, E., Clinica chim. Acta48 (1973) 159.
Smith, S. L.; Novotny, M., and Weber, E. L., Clin. Chem.24 (1978) 545.
Servo, C. and Pitkänen, E., Diabetologia11 (1975) 575.
Akanuma, Y., Yamanouchi, T., Kadowaki, T., Iwamoto, Y., and Akanuma, H., Diabetes31, suppl. 2 (1982) abstract 621.
Pitkänen, E., Scand. J. clin. Lab. Invest.42 (1982) 445.
Carr, J., and Krantz, J. D., J. Am. pharmac. Ass.27 (1938) 318.
Sakata, T., Tsutsui, K., Fukushima, M., Arase, K., Kita, H., Oomura, Y., Ohki, K., and Nicolaidis, S., Physiol. Behav.27 (1981) 401.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Pitkänen, E., Pitkänen, O. The elimination of 1,5-anhydroglucitol administered to rats. Experientia 40, 463–465 (1984). https://doi.org/10.1007/BF01952387
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF01952387