Experientia

, Volume 36, Issue 3, pp 321–323 | Cite as

Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation?

  • H. Sinzinger
  • P. Clopath
  • K. Silberbauer
  • M. Winter
Specialia

Summary

Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.

Keywords

Atherosclerosis Arterial Wall Vascular System Prostacyclin Vascular Effect 

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • H. Sinzinger
    • 1
    • 2
    • 3
  • P. Clopath
    • 1
    • 2
    • 3
  • K. Silberbauer
    • 1
    • 2
    • 3
  • M. Winter
    • 1
    • 2
    • 3
  1. 1.Atherosclerosis Research Group at the Department of Medical PhysiologyVienna(Austria)
  2. 2.Pharma Research DivisionCiba-Geigy AGBasle(Switzerland)
  3. 3.2nd Department of Internal Medicine and 1st Department of SurgeryUniversity of ViennaVienna(Austria)

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