Summary
Species exhibiting a higher susceptibility to the development of atherosclerosis have a reduced prostacyclin (PGI2)-generation in the arterial wall, which differs in various parts of the vascular system. As the difference in PGI2-formation in various diseases is a generalized vascular effect, the changes can be detected in all vessels. This is a very important point for diagnostic purposes in humans.
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This study was supported by a grant of the «Fonds 600 Jahre Wiener Universität der Kammer der gewerblichen Wirtschaft für Wien».
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Sinzinger, H., Clopath, P., Silberbauer, K. et al. Is the variation in the susceptibility of various species to atherosclerosis due to inborn differences in prostacyclin (PGI2) formation?. Experientia 36, 321–323 (1980). https://doi.org/10.1007/BF01952302
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DOI: https://doi.org/10.1007/BF01952302