Experientia

, Volume 36, Issue 3, pp 291–292 | Cite as

Mutagenicity of melanin from human red hair

  • Z. P. Harsanyl
  • P. W. Post
  • Jeannie P. Brinkmann
  • M. R. Chedekel
  • Rose Marie Deibel
Specialia

Summary

TheSalmonella typhimurium histidine reversion test of Ames et al. was used to demonstrate that pheomelanin, the red-brown polymeric pigment produced in human skin and hair, becomes mutagenic after exposure to long wave-length UV-light; a finding consistent with the UV-induced somatic mutation hypothesis for the origin of freckles and the high susceptibility of redheads and blonds to sunlight-induced skin cancers.

Keywords

Histidine Human Skin Skin Cancer Somatic Mutation High Susceptibility 

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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Z. P. Harsanyl
    • 1
    • 3
    • 2
  • P. W. Post
    • 1
    • 3
    • 2
  • Jeannie P. Brinkmann
    • 1
    • 3
    • 2
  • M. R. Chedekel
    • 1
    • 3
    • 2
  • Rose Marie Deibel
    • 1
    • 3
    • 2
  1. 1.Departments of Microbiology and Medicine (Dermatology Division)Cornell University Medical CollegeNew YorkUSA
  2. 2.Department of Field ofGeneticsCornell University Medical CollegeNew YorkUSA
  3. 3.Department of ChemistryThe Ohio State UniversityColumbusUSA

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