, Volume 36, Issue 3, pp 291–292 | Cite as

Mutagenicity of melanin from human red hair

  • Z. P. Harsanyl
  • P. W. Post
  • Jeannie P. Brinkmann
  • M. R. Chedekel
  • Rose Marie Deibel


TheSalmonella typhimurium histidine reversion test of Ames et al. was used to demonstrate that pheomelanin, the red-brown polymeric pigment produced in human skin and hair, becomes mutagenic after exposure to long wave-length UV-light; a finding consistent with the UV-induced somatic mutation hypothesis for the origin of freckles and the high susceptibility of redheads and blonds to sunlight-induced skin cancers.


Histidine Human Skin Skin Cancer Somatic Mutation High Susceptibility 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Birkhäuser Verlag 1980

Authors and Affiliations

  • Z. P. Harsanyl
    • 1
    • 3
    • 2
  • P. W. Post
    • 1
    • 3
    • 2
  • Jeannie P. Brinkmann
    • 1
    • 3
    • 2
  • M. R. Chedekel
    • 1
    • 3
    • 2
  • Rose Marie Deibel
    • 1
    • 3
    • 2
  1. 1.Departments of Microbiology and Medicine (Dermatology Division)Cornell University Medical CollegeNew YorkUSA
  2. 2.Department of Field ofGeneticsCornell University Medical CollegeNew YorkUSA
  3. 3.Department of ChemistryThe Ohio State UniversityColumbusUSA

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