Experientia

, Volume 44, Issue 2, pp 97–100 | Cite as

Cytosolic calcium in platelet activation

  • T. J. Rink
Multi-author Review The Platelet in Pathophysiological Research

Summary

Experiments with permeabilised platelets, and with intact platelets loaded with fluorescent Ca2+-indicators, over the past several years have greatly extended our knowledge and understanding of cytosolic Ca2+ as a platelet activator and its interactions with other cytosolic regulators. This article outlines insights, gained from the use of the fluorescent dyes, into maintenance and restoration of basal [Ca2+]i, mechanisms of receptor-mediated Ca2+-mobilisation and quantitation of [Ca2+]i/response relations in intact human platelets.

Key words

Calcium platelet second messenger 

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Copyright information

© Birkhäuser Verlag 1988

Authors and Affiliations

  • T. J. Rink
    • 1
  1. 1.Smith Kline & French Research LtdWelwyn(England)

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